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IID00452
 UniprotP48382
ProteinDNA-binding protein RFX5
GeneRFX5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
616
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 24-90 Hetero trimer : IID00425Complex
 Evidence NMR 2kw3 A Reference
       Region 2kw3 A 24-90 order
       Region 2kw3 A 24-26 high_rmsd
       Region 2kw3 A 69-90 high_rmsd
 Evidence NMR 2kw3 B Reference
       Region 2kw3 B 24-90 order
       Region 2kw3 B 24-27 high_rmsd
       Region 2kw3 B 72-90 high_rmsd
Seq 167-183 Hetero dimer : IID00427Complex
 Evidence X-RAY 3v30 B Reference
       Region 3v30 B 167-167 disorder
       Region 3v30 B 168-183 order
Seqphosphorylation
    10-10 Phosphoserine
    185-185 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-64,69-88,175-201,243-616
Order 65-68,89-174,202-242
ProS 1-6,27-55,60-64,175-179,197-201,243-247,322-332,350-354,549-559,563-574,589-598
AlphaFold
Disorder 1-27,71-83,126-126,169-173,175-175,177-196,249-614,616-616
Order 28-70,84-125,127-168,174-174,176-176,197-248,615-615
Pfam Hmmer
PF02257 76-158 7.3e-55
SEG 13-29 ,324-354 ,389-406 ,463-477 ,504-516
Function
Function in SwissProt
Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
Biological Process
See also
Diagram with PDB data
RFXANK/FRX5Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human RFXANK