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IID00453
 UniprotP50616
ProteinProtein Tob1
GeneTOB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
345
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-115 Hetero dimer : IID00504Complex
 Evidence X-RAY 2d5r B Reference
       Region 2d5r B 1-115 order
Seq 1-117 Homo tetramer :
 Evidence X-RAY 2z15 A Reference
       Region 2z15 A 1-117 order
 Evidence X-RAY 2z15 B Reference
       Region 2z15 B 1-116 order
       Region 2z15 B 117-117 disorder
 Evidence X-RAY 2z15 C Reference
       Region 2z15 C 1-116 order
       Region 2z15 C 117-117 disorder
 Evidence X-RAY 2z15 D Reference
       Region 2z15 D 1-116 order
       Region 2z15 D 117-117 disorder
Seq 1-345 Monomer :
 Evidence X-RAY 5ci9 A Reference
       Region 5ci9 A 1-115 order
       Region 5ci9 A 116-345 disorder
 Evidence X-RAY 5ci8 A Reference
       Region 5ci8 A 1-115 order
       Region 5ci8 A 116-345 disorder
Seqphosphorylation
    204-204 Phosphothreonine
 
Prediction
NeProc
Disorder 127-318
Order 1-126,319-345
ProS 127-148,166-189,207-218,268-277,287-294,315-318
AlphaFold
Disorder 118-132,134-176,187-248,256-345
Order 1-117,133-133,177-186,249-255
Pfam Hmmer
PF07742 1-115 6.1e-77
SEG 30-39 ,141-160 ,176-187 ,237-262
Function
Function in SwissProt
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).