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IID00457
 UniprotP56524
ProteinHistone deacetylase 4
GeneHDAC4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1084
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 62-153 Homo tetramer :
 Evidence X-RAY 2o94 D Reference
       Region 2o94 D 62-129 order
       Region 2o94 D 130-153 disorder
 Evidence X-RAY 2o94 C Reference
       Region 2o94 C 62-129 order
       Region 2o94 C 130-153 disorder
 Evidence X-RAY 2o94 B Reference
       Region 2o94 B 62-129 order
       Region 2o94 B 130-153 disorder
 Evidence X-RAY 2o94 A Reference
       Region 2o94 A 62-129 order
       Region 2o94 A 130-153 disorder
 Evidence X-RAY 2h8n D Reference
       Region 2h8n D 62-129 order
       Region 2h8n D 130-153 disorder
 Evidence X-RAY 2h8n C Reference
       Region 2h8n C 62-129 order
       Region 2h8n C 130-153 disorder
 Evidence X-RAY 2h8n B Reference
       Region 2h8n B 62-129 order
       Region 2h8n B 130-153 disorder
 Evidence X-RAY 2h8n A Reference
       Region 2h8n A 62-129 order
       Region 2h8n A 130-153 disorder
Seq 343-359 Hetero dimer : IID00427Complex
 Evidence X-RAY 3uxg B Reference
       Region 3uxg B 343-343 disorder
       Region 3uxg B 344-359 order
Seq 343-359 Hetero dimer : P61981
 Evidence X-RAY 3uzd B Reference
       Region 3uzd B 343-347 disorder
       Region 3uzd B 348-356 order
       Region 3uzd B 357-359 disorder
Seq 343-359 Hetero dimer : Q9H9E1
 Evidence X-RAY 3v31 B Reference
       Region 3v31 B 343-359 order
Seq 648-1057 Homo dimer :
 Evidence X-RAY 2vqo A Reference
       Region 2vqo A 648-650 disorder
       Region 2vqo A 651-666 order
       Region 2vqo A 667-678 disorder
       Region 2vqo A 679-728 order
       Region 2vqo A 729-755 disorder
       Region 2vqo A 756-1049 order
       Region 2vqo A 1050-1057 disorder
 Evidence X-RAY 2vqo B Reference
       Region 2vqo B 648-650 disorder
       Region 2vqo B 651-665 order
       Region 2vqo B 666-678 disorder
       Region 2vqo B 679-728 order
       Region 2vqo B 729-756 disorder
       Region 2vqo B 757-1049 order
       Region 2vqo B 1050-1057 disorder
Seq 648-1057 Monomer :
 Evidence X-RAY 2vqw G Reference
       Region 2vqw G 648-650 disorder
       Region 2vqw G 651-669 order
       Region 2vqw G 670-672 disorder
       Region 2vqw G 673-728 order
       Region 2vqw G 729-743 disorder
       Region 2vqw G 744-1050 order
       Region 2vqw G 1051-1057 disorder
 Evidence X-RAY 2vqv B Reference
       Region 2vqv B 648-650 disorder
       Region 2vqv B 651-664 order
       Region 2vqv B 665-677 disorder
       Region 2vqv B 678-728 order
       Region 2vqv B 729-758 disorder
       Region 2vqv B 759-1049 order
       Region 2vqv B 1050-1057 disorder
 Evidence X-RAY 2vqv A Reference
       Region 2vqv A 648-650 disorder
       Region 2vqv A 651-664 order
       Region 2vqv A 665-678 disorder
       Region 2vqv A 679-727 order
       Region 2vqv A 728-758 disorder
       Region 2vqv A 759-1049 order
       Region 2vqv A 1050-1057 disorder
 Evidence X-RAY 2vqq B Reference
       Region 2vqq B 648-650 disorder
       Region 2vqq B 651-665 order
       Region 2vqq B 666-679 disorder
       Region 2vqq B 680-728 order
       Region 2vqq B 729-756 disorder
       Region 2vqq B 757-1049 order
       Region 2vqq B 1050-1057 disorder
 Evidence X-RAY 2vqq A Reference
       Region 2vqq A 648-650 disorder
       Region 2vqq A 651-666 order
       Region 2vqq A 667-677 disorder
       Region 2vqq A 678-728 order
       Region 2vqq A 729-755 disorder
       Region 2vqq A 756-1049 order
       Region 2vqq A 1050-1057 disorder
 Evidence X-RAY 2vqm A Reference
       Region 2vqm A 648-649 disorder
       Region 2vqm A 650-670 order
       Region 2vqm A 671-677 disorder
       Region 2vqm A 678-731 order
       Region 2vqm A 732-735 disorder
       Region 2vqm A 736-1051 order
       Region 2vqm A 1052-1057 disorder
 Evidence X-RAY 2vqj A Reference
       Region 2vqj A 648-649 disorder
       Region 2vqj A 650-1051 order
       Region 2vqj A 1052-1057 disorder
 Evidence X-RAY 4cby D Reference
       Region 4cby D 648-652 disorder
       Region 4cby D 653-1033 order
 Evidence X-RAY 4cby C Reference
       Region 4cby C 648-652 disorder
       Region 4cby C 653-1032 order
       Region 4cby C 1033-1033 disorder
 Evidence X-RAY 4cby B Reference
       Region 4cby B 648-651 disorder
       Region 4cby B 652-1031 order
       Region 4cby B 1032-1033 disorder
 Evidence X-RAY 4cby A Reference
       Region 4cby A 648-652 disorder
       Region 4cby A 653-1032 order
       Region 4cby A 1033-1033 disorder
 Evidence X-RAY 4cbt C Reference
       Region 4cbt C 648-669 order
       Region 4cbt C 670-673 disorder
       Region 4cbt C 674-728 order
       Region 4cbt C 729-759 disorder
       Region 4cbt C 760-829 order
       Region 4cbt C 830-831 disorder
       Region 4cbt C 832-996 order
       Region 4cbt C 997-1002 disorder
       Region 4cbt C 1003-1033 order
 Evidence X-RAY 4cbt B Reference
       Region 4cbt B 648-648 disorder
       Region 4cbt B 649-727 order
       Region 4cbt B 728-757 disorder
       Region 4cbt B 758-995 order
       Region 4cbt B 996-997 disorder
       Region 4cbt B 998-1032 order
       Region 4cbt B 1033-1033 disorder
 Evidence X-RAY 4cbt A Reference
       Region 4cbt A 648-649 disorder
       Region 4cbt A 650-728 order
       Region 4cbt A 729-757 disorder
       Region 4cbt A 758-997 order
       Region 4cbt A 998-1004 disorder
       Region 4cbt A 1005-1033 order
 Evidence X-RAY 5a2s B Reference
       Region 5a2s B 648-652 disorder
       Region 5a2s B 653-1032 order
       Region 5a2s B 1033-1033 disorder
 Evidence X-RAY 5a2s A Reference
       Region 5a2s A 648-652 disorder
       Region 5a2s A 653-1032 order
       Region 5a2s A 1033-1033 disorder
Seqphosphorylation
    210-210 Phosphoserine
    246-246 Phosphoserine; by CaMK4 and SIK1
    350-350 Phosphoserine
    467-467 Phosphoserine; by CaMK4 and SIK1
    565-565 Phosphoserine
    632-632 Phosphoserine; by CaMK4
    633-633 Phosphoserine
 
Prediction
NeProc
Disorder 1-89,173-652,736-740,1043-1084
Order 90-172,653-735,741-1042
ProS 7-40,48-56,70-78,85-89,173-191,199-204,235-278,341-359,459-464,505-509,586-605,617-633,736-740,1043-1066,1077-1084
AlphaFold
Disorder 1-64,154-167,188-594,597-597,608-608,611-650,727-744,1034-1034,1064-1084
Order 65-153,168-187,595-596,598-607,609-610,651-726,745-1033,1035-1063
Pfam Hmmer
PF00850 653-998 4e-109
SEG 65-89 ,149-163 ,290-312 ,474-503 ,519-531 ,561-578 ,1070-1083
Function
Function in SwissProt
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).
Biological Process
Diagram with PDB data
HDAC4/YWHAGCrystal structure of 14-3-3 GAMMA
HDAC4/ANKRA2Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2
HDAC4/RFXANKCrystal structure of RFXANK