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IID00459
 UniprotP62993
ProteinGrowth factor receptor-bound protein 2
GeneGRB2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
217
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-56 Hetero dimer : IID50185Complex
 Evidence NMR 1aze A Reference
       Region 1aze A 1-56 order
Seq 1-217 Homo dimer :
 Evidence X-RAY 1gri B Reference
       Region 1gri B 1-27 order
       Region 1gri B 28-33 disorder
       Region 1gri B 34-217 order
 Evidence X-RAY 1gri A Reference
       Region 1gri A 1-27 order
       Region 1gri A 28-33 disorder
       Region 1gri A 34-217 order
Seq 49-163 Monomer :
 Evidence NMR 1x0n A Reference
       Region 1x0n A 58-59 disorder
       Region 1x0n A 60-159 order
       Region 1x0n A 158-159 high_rmsd
 Evidence X-RAY 3in8 A Reference
       Region 3in8 A 53-54 disorder
       Region 3in8 A 55-155 order
       Region 3in8 A 156-163 disorder
 Evidence NMR 1ghu A Reference
       Region 1ghu A 60-152 order
       Region 1ghu A 153-158 disorder
 Evidence NMR 1fhs A Reference
       Region 1fhs A 53-163 order
       Region 1fhs A 53-57 high_rmsd
       Region 1fhs A 114-114 high_rmsd
       Region 1fhs A 157-163 high_rmsd
 Evidence X-RAY 1zfp E Reference
       Region 1zfp E 56-153 order
 Evidence X-RAY 1tze E Reference
       Region 1tze E 55-152 order
 Evidence X-RAY 3s8o A Reference
       Region 3s8o A 53-53 disorder
       Region 3s8o A 54-154 order
       Region 3s8o A 155-163 disorder
 Evidence X-RAY 3s8n A Reference
       Region 3s8n A 53-53 disorder
       Region 3s8n A 54-154 order
       Region 3s8n A 155-163 disorder
 Evidence X-RAY 3s8l A Reference
       Region 3s8l A 53-53 disorder
       Region 3s8l A 54-154 order
       Region 3s8l A 155-163 disorder
 Evidence X-RAY 4p9z A Reference
       Region 4p9z A 53-53 disorder
       Region 4p9z A 54-162 order
       Region 4p9z A 163-163 disorder
 Evidence X-RAY 4p9v A Reference
       Region 4p9v A 53-53 disorder
       Region 4p9v A 54-153 order
       Region 4p9v A 154-163 disorder
 Evidence X-RAY 3ove A Reference
       Region 3ove A 53-53 disorder
       Region 3ove A 54-154 order
       Region 3ove A 155-163 disorder
 Evidence X-RAY 3ov1 A Reference
       Region 3ov1 A 53-54 disorder
       Region 3ov1 A 55-155 order
       Region 3ov1 A 156-163 disorder
 Evidence X-RAY 3n8m A Reference
       Region 3n8m A 53-54 disorder
       Region 3n8m A 55-153 order
       Region 3n8m A 154-163 disorder
 Evidence X-RAY 3n84 F Reference
       Region 3n84 F 53-153 order
       Region 3n84 F 154-163 disorder
 Evidence X-RAY 3n84 E Reference
       Region 3n84 E 53-153 order
       Region 3n84 E 154-163 disorder
 Evidence X-RAY 3n84 D Reference
       Region 3n84 D 53-53 disorder
       Region 3n84 D 54-154 order
       Region 3n84 D 155-163 disorder
 Evidence X-RAY 3n84 C Reference
       Region 3n84 C 53-54 disorder
       Region 3n84 C 55-163 order
 Evidence X-RAY 3n84 B Reference
       Region 3n84 B 53-53 disorder
       Region 3n84 B 54-159 order
       Region 3n84 B 160-163 disorder
 Evidence X-RAY 3n84 A Reference
       Region 3n84 A 53-54 disorder
       Region 3n84 A 55-163 order
 Evidence X-RAY 3n7y C Reference
       Region 3n7y C 55-152 order
 Evidence X-RAY 3n7y B Reference
       Region 3n7y B 55-152 order
 Evidence X-RAY 3n7y A Reference
       Region 3n7y A 55-152 order
 Evidence X-RAY 3kfj A Reference
       Region 3kfj A 53-55 disorder
       Region 3kfj A 56-155 order
       Region 3kfj A 156-163 disorder
 Evidence X-RAY 1jyu A Reference
       Region 1jyu A 60-151 order
 Evidence X-RAY 3in7 C Reference
       Region 3in7 C 53-54 disorder
       Region 3in7 C 55-154 order
       Region 3in7 C 155-163 disorder
 Evidence X-RAY 3in7 A Reference
       Region 3in7 A 53-54 disorder
       Region 3in7 A 55-153 order
       Region 3in7 A 154-163 disorder
 Evidence X-RAY 3imj B Reference
       Region 3imj B 53-55 disorder
       Region 3imj B 56-155 order
       Region 3imj B 156-163 disorder
 Evidence X-RAY 3imj A Reference
       Region 3imj A 53-54 disorder
       Region 3imj A 55-155 order
       Region 3imj A 156-163 disorder
 Evidence X-RAY 3imd B Reference
       Region 3imd B 53-54 disorder
       Region 3imd B 55-155 order
       Region 3imd B 156-163 disorder
 Evidence X-RAY 3imd A Reference
       Region 3imd A 53-54 disorder
       Region 3imd A 55-155 order
       Region 3imd A 156-163 disorder
 Evidence X-RAY 2huw B Reference
       Region 2huw B 53-55 disorder
       Region 2huw B 56-153 order
       Region 2huw B 154-162 disorder
 Evidence X-RAY 2huw A Reference
       Region 2huw A 53-54 disorder
       Region 2huw A 55-155 order
       Region 2huw A 156-162 disorder
 Evidence X-RAY 1bm2 A Reference
       Region 1bm2 A 49-54 disorder
       Region 1bm2 A 55-152 order
       Region 1bm2 A 153-163 disorder
 Evidence X-RAY 2aob D Reference
       Region 2aob D 55-58 disorder
       Region 2aob D 59-151 order
       Region 2aob D 152-153 disorder
 Evidence X-RAY 2aob C Reference
       Region 2aob C 55-55 disorder
       Region 2aob C 56-151 order
       Region 2aob C 152-153 disorder
 Evidence X-RAY 2aob B Reference
       Region 2aob B 55-58 disorder
       Region 2aob B 59-151 order
       Region 2aob B 152-153 disorder
 Evidence X-RAY 2aob A Reference
       Region 2aob A 55-55 disorder
       Region 2aob A 56-151 order
       Region 2aob A 152-153 disorder
 Evidence X-RAY 2aoa B Reference
       Region 2aoa B 55-67 disorder
       Region 2aoa B 68-87 order
       Region 2aoa B 88-92 disorder
       Region 2aoa B 93-149 order
       Region 2aoa B 150-153 disorder
 Evidence X-RAY 2aoa A Reference
       Region 2aoa A 55-57 disorder
       Region 2aoa A 58-150 order
       Region 2aoa A 151-153 disorder
Seq 49-168 Hetero dimer :
 Evidence X-RAY 1bmb A Reference
       Region 1bmb A 49-55 disorder
       Region 1bmb A 56-153 order
       Region 1bmb A 154-168 disorder
Seq 50-161 Hetero tetramer : IID00704Complex
 Evidence X-RAY 1fyr D Reference
       Region 1fyr D 50-57 disorder
       Region 1fyr D 58-152 order
       Region 1fyr D 153-161 disorder
 Evidence X-RAY 1fyr C Reference
       Region 1fyr C 50-54 disorder
       Region 1fyr C 55-152 order
       Region 1fyr C 153-161 disorder
Seq 50-161 Hetero tetramer : IID00704Complex
 Evidence X-RAY 1fyr B Reference
       Region 1fyr B 50-54 disorder
       Region 1fyr B 55-152 order
       Region 1fyr B 153-161 disorder
 Evidence X-RAY 1fyr A Reference
       Region 1fyr A 50-57 disorder
       Region 1fyr A 58-152 order
       Region 1fyr A 153-161 disorder
Seq 53-162 Homo dimer :
 Evidence X-RAY 1jyq B Reference
       Region 1jyq B 60-151 order
 Evidence X-RAY 1jyq A Reference
       Region 1jyq A 60-151 order
 Evidence X-RAY 2h5k B Reference
       Region 2h5k B 53-56 disorder
       Region 2h5k B 57-152 order
       Region 2h5k B 153-162 disorder
 Evidence X-RAY 2h5k A Reference
       Region 2h5k A 53-56 disorder
       Region 2h5k A 57-152 order
       Region 2h5k A 153-162 disorder
 Evidence X-RAY 2h46 E Reference
       Region 2h46 E 53-54 disorder
       Region 2h46 E 55-152 order
       Region 2h46 E 153-162 disorder
 Evidence X-RAY 1cj1 L Reference
       Region 1cj1 L 57-152 order
 Evidence X-RAY 1cj1 K Reference
       Region 1cj1 K 57-152 order
 Evidence X-RAY 1cj1 J Reference
       Region 1cj1 J 57-152 order
 Evidence X-RAY 1cj1 I Reference
       Region 1cj1 I 57-152 order
 Evidence X-RAY 1cj1 H Reference
       Region 1cj1 H 57-152 order
 Evidence X-RAY 1cj1 G Reference
       Region 1cj1 G 57-152 order
 Evidence X-RAY 1cj1 F Reference
       Region 1cj1 F 57-152 order
 Evidence X-RAY 1cj1 E Reference
       Region 1cj1 E 57-152 order
 Evidence X-RAY 1cj1 D Reference
       Region 1cj1 D 57-152 order
 Evidence X-RAY 1cj1 C Reference
       Region 1cj1 C 57-152 order
 Evidence X-RAY 1cj1 B Reference
       Region 1cj1 B 57-152 order
 Evidence X-RAY 1cj1 A Reference
       Region 1cj1 A 57-152 order
 Evidence X-RAY 3c7i A Reference
       Region 3c7i A 53-54 disorder
       Region 3c7i A 55-155 order
       Region 3c7i A 156-162 disorder
Seq 54-153 Hetero 32mer :
 Evidence X-RAY 5cdw d Reference
       Region 5cdw d 54-54 disorder
       Region 5cdw d 55-152 order
       Region 5cdw d 153-153 disorder
 Evidence X-RAY 5cdw c Reference
       Region 5cdw c 55-152 order
       Region 5cdw c 153-153 disorder
 Evidence X-RAY 5cdw Z Reference
       Region 5cdw Z 54-55 disorder
       Region 5cdw Z 56-152 order
       Region 5cdw Z 153-153 disorder
 Evidence X-RAY 5cdw Y Reference
       Region 5cdw Y 54-54 disorder
       Region 5cdw Y 55-153 order
 Evidence X-RAY 5cdw V Reference
       Region 5cdw V 54-55 disorder
       Region 5cdw V 56-152 order
       Region 5cdw V 153-153 disorder
 Evidence X-RAY 5cdw U Reference
       Region 5cdw U 54-55 disorder
       Region 5cdw U 56-153 order
 Evidence X-RAY 5cdw P Reference
       Region 5cdw P 54-56 disorder
       Region 5cdw P 57-152 order
       Region 5cdw P 153-153 disorder
 Evidence X-RAY 5cdw O Reference
       Region 5cdw O 54-54 disorder
       Region 5cdw O 55-152 order
       Region 5cdw O 153-153 disorder
 Evidence X-RAY 5cdw L Reference
       Region 5cdw L 54-54 disorder
       Region 5cdw L 55-152 order
       Region 5cdw L 153-153 disorder
 Evidence X-RAY 5cdw K Reference
       Region 5cdw K 54-153 order
 Evidence X-RAY 5cdw H Reference
       Region 5cdw H 54-55 disorder
       Region 5cdw H 56-152 order
       Region 5cdw H 153-153 disorder
 Evidence X-RAY 5cdw G Reference
       Region 5cdw G 54-153 order
 Evidence X-RAY 5cdw E Reference
       Region 5cdw E 54-54 disorder
       Region 5cdw E 55-153 order
 Evidence X-RAY 5cdw C Reference
       Region 5cdw C 54-54 disorder
       Region 5cdw C 55-153 order
 Evidence X-RAY 5cdw B Reference
       Region 5cdw B 54-153 order
 Evidence X-RAY 5cdw A Reference
       Region 5cdw A 54-55 disorder
       Region 5cdw A 56-153 order
Seq 55-152 Hetero dimer : IID00294Complex
 Evidence X-RAY 3mxy A Reference
       Region 3mxy A 55-152 order
 Evidence X-RAY 3mxc A Reference
       Region 3mxc A 55-152 order
Seq 58-159 Hetero dimer : IID00511Complex
 Evidence NMR 1qg1 E Reference
       Region 1qg1 E 58-159 order
Seq 60-151 Hetero dimer :
 Evidence X-RAY 1jyr A Reference
       Region 1jyr A 60-151 order
Seq 60-152 Hetero dimer : IID00509Complex
 Evidence X-RAY 3wa4 A Reference
       Region 3wa4 A 60-152 order
Seq 159-214 Hetero dimer : IID00522Complex
 Evidence X-RAY 2vwf A Reference
       Region 2vwf A 159-214 order
Seq 159-214 Hetero dimer : IID00522Complex
 Evidence X-RAY 2w0z A Reference
       Region 2w0z A 159-214 order
Seq 159-215 Monomer :
 Evidence X-RAY 2vvk A Reference
       Region 2vvk A 161-214 order
 Evidence NMR 1gfd A Reference
       Region 1gfd A 159-215 order
       Region 1gfd A 215-215 high_rmsd
 Evidence NMR 1gfc A Reference
       Region 1gfc A 159-215 order
Seq 159-215 Hetero dimer :
 Evidence 1io6 A Reference
       Region 1io6 A 159-215 order
Seq 159-217 Hetero trimer : P27870
 Evidence X-RAY 1gcq B Reference
       Region 1gcq B 159-215 order
       Region 1gcq B 216-217 disorder
 Evidence X-RAY 1gcq A Reference
       Region 1gcq A 159-213 order
       Region 1gcq A 214-217 disorder
Seqphosphorylation
    211-211 Phosphothreonine
Seqacetylation
    109-109 N6-acetyllysine
    50-50 N6-acetyllysine
    6-6 N6-acetyllysine
    1-1 N-acetylmethionine
 
Prediction
NeProc
Order 1-217
AlphaFold
Disorder 30-33,153-159,214-217
Order 1-29,34-152,160-213
Pfam Hmmer
PF00018 1-56 2.2e-23
PF00017 60-135 3.4e-37
PF00018 159-213 2.6e-25
Function
Function in SwissProt
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Isoform 2
Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Biological Process
See also
Diagram with PDB data
MET/GRB2DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX
GAB2/GRB2Grb2 SH3C (3)