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IID00460
 UniprotP98177
ProteinForkhead box protein O4
GeneFOXO4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
505
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 86-211 Monomer :
 Evidence NMR 1e17 A Reference
       Region 1e17 A 86-95 disorder
       Region 1e17 A 96-185 order
       Region 1e17 A 96-99 high_rmsd
       Region 1e17 A 173-173 high_rmsd
       Region 1e17 A 184-185 high_rmsd
       Region 1e17 A 186-211 disorder
 Evidence X-RAY 3l2c A Reference
       Region 3l2c A 86-96 disorder
       Region 3l2c A 97-181 order
       Region 3l2c A 182-187 disorder
Seqphosphorylation
    262-262 Phosphoserine; by PKB/AKT1
    197-197 Phosphoserine; by PKB/AKT1
    32-32 Phosphothreonine; by PKB/AKT1
 
Prediction
NeProc
Disorder 1-99,186-481,502-505
Order 100-142,148-185,482-501
ProS 1-6,14-43,186-193,199-204,239-257,307-312,342-346,448-453,466-481,502-505
AlphaFold
Disorder 1-22,24-97,146-146,172-172,184-191,200-436,438-482,484-505
Order 23-23,98-145,147-171,173-183,192-199,437-437,483-483
Pfam Hmmer
PF00250 47-193 1.9e-25
SEG 257-272 ,299-329 ,390-409
Function
Function in SwissProt
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Biological Process
Diagram without PDB data
FOXO4Stress signals in FOXO regulation