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IID00462
 UniprotQ02880
ProteinDNA topoisomerase 2-beta
GeneTOP2B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1626
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 450-1206 Homo dimer :
 Evidence X-RAY 3qx3 B Reference
       Region 3qx3 B 450-453 disorder
       Region 3qx3 B 454-597 order
       Region 3qx3 B 598-641 disorder
       Region 3qx3 B 642-700 order
       Region 3qx3 B 701-710 disorder
       Region 3qx3 B 711-967 order
       Region 3qx3 B 968-971 disorder
       Region 3qx3 B 972-1115 order
       Region 3qx3 B 1116-1139 disorder
       Region 3qx3 B 1140-1206 order
 Evidence X-RAY 3qx3 A Reference
       Region 3qx3 A 450-456 disorder
       Region 3qx3 A 457-596 order
       Region 3qx3 A 597-642 disorder
       Region 3qx3 A 643-701 order
       Region 3qx3 A 702-711 disorder
       Region 3qx3 A 712-1116 order
       Region 3qx3 A 1117-1139 disorder
       Region 3qx3 A 1140-1206 order
 Evidence X-RAY 4j3n B Reference
       Region 4j3n B 450-453 disorder
       Region 4j3n B 454-597 order
       Region 4j3n B 598-641 disorder
       Region 4j3n B 642-700 order
       Region 4j3n B 701-710 disorder
       Region 4j3n B 711-966 order
       Region 4j3n B 967-971 disorder
       Region 4j3n B 972-1115 order
       Region 4j3n B 1116-1139 disorder
       Region 4j3n B 1140-1206 order
 Evidence X-RAY 4j3n A Reference
       Region 4j3n A 450-459 disorder
       Region 4j3n A 460-596 order
       Region 4j3n A 597-644 disorder
       Region 4j3n A 645-701 order
       Region 4j3n A 702-711 disorder
       Region 4j3n A 712-1116 order
       Region 4j3n A 1117-1139 disorder
       Region 4j3n A 1140-1206 order
 Evidence X-RAY 5gwj B Reference
       Region 5gwj B 450-453 disorder
       Region 5gwj B 454-597 order
       Region 5gwj B 598-641 disorder
       Region 5gwj B 642-700 order
       Region 5gwj B 701-710 disorder
       Region 5gwj B 711-1116 order
       Region 5gwj B 1117-1139 disorder
       Region 5gwj B 1140-1206 order
 Evidence X-RAY 5gwj A Reference
       Region 5gwj A 450-456 disorder
       Region 5gwj A 457-598 order
       Region 5gwj A 599-638 disorder
       Region 5gwj A 639-701 order
       Region 5gwj A 702-711 disorder
       Region 5gwj A 712-1116 order
       Region 5gwj A 1117-1139 disorder
       Region 5gwj A 1140-1206 order
 Evidence X-RAY 5gwi B Reference
       Region 5gwi B 450-453 disorder
       Region 5gwi B 454-597 order
       Region 5gwi B 598-641 disorder
       Region 5gwi B 642-700 order
       Region 5gwi B 701-710 disorder
       Region 5gwi B 711-967 order
       Region 5gwi B 968-971 disorder
       Region 5gwi B 972-1115 order
       Region 5gwi B 1116-1139 disorder
       Region 5gwi B 1140-1206 order
 Evidence X-RAY 5gwi A Reference
       Region 5gwi A 450-456 disorder
       Region 5gwi A 457-596 order
       Region 5gwi A 597-642 disorder
       Region 5gwi A 643-701 order
       Region 5gwi A 702-711 disorder
       Region 5gwi A 712-1116 order
       Region 5gwi A 1117-1139 disorder
       Region 5gwi A 1140-1206 order
 Evidence X-RAY 4g0w B Reference
       Region 4g0w B 450-453 disorder
       Region 4g0w B 454-597 order
       Region 4g0w B 598-648 disorder
       Region 4g0w B 649-700 order
       Region 4g0w B 701-710 disorder
       Region 4g0w B 711-967 order
       Region 4g0w B 968-971 disorder
       Region 4g0w B 972-1115 order
       Region 4g0w B 1116-1139 disorder
       Region 4g0w B 1140-1206 order
 Evidence X-RAY 4g0w A Reference
       Region 4g0w A 450-456 disorder
       Region 4g0w A 457-596 order
       Region 4g0w A 597-649 disorder
       Region 4g0w A 650-701 order
       Region 4g0w A 702-711 disorder
       Region 4g0w A 712-1116 order
       Region 4g0w A 1117-1139 disorder
       Region 4g0w A 1140-1206 order
 Evidence X-RAY 4g0v B Reference
       Region 4g0v B 450-453 disorder
       Region 4g0v B 454-595 order
       Region 4g0v B 596-641 disorder
       Region 4g0v B 642-698 order
       Region 4g0v B 699-711 disorder
       Region 4g0v B 712-967 order
       Region 4g0v B 968-971 disorder
       Region 4g0v B 972-1115 order
       Region 4g0v B 1116-1139 disorder
       Region 4g0v B 1140-1206 order
 Evidence X-RAY 4g0v A Reference
       Region 4g0v A 450-456 disorder
       Region 4g0v A 457-596 order
       Region 4g0v A 597-650 disorder
       Region 4g0v A 651-701 order
       Region 4g0v A 702-711 disorder
       Region 4g0v A 712-1116 order
       Region 4g0v A 1117-1139 disorder
       Region 4g0v A 1140-1206 order
 Evidence X-RAY 4g0u B Reference
       Region 4g0u B 450-457 disorder
       Region 4g0u B 458-595 order
       Region 4g0u B 596-640 disorder
       Region 4g0u B 641-698 order
       Region 4g0u B 699-710 disorder
       Region 4g0u B 711-1115 order
       Region 4g0u B 1116-1139 disorder
       Region 4g0u B 1140-1206 order
 Evidence X-RAY 4g0u A Reference
       Region 4g0u A 450-459 disorder
       Region 4g0u A 460-596 order
       Region 4g0u A 597-652 disorder
       Region 4g0u A 653-698 order
       Region 4g0u A 699-711 disorder
       Region 4g0u A 712-1116 order
       Region 4g0u A 1117-1139 disorder
       Region 4g0u A 1140-1206 order
Seqphosphorylation
    1236-1236 Phosphoserine
    1292-1292 Phosphothreonine
    1336-1336 Phosphoserine
    1340-1340 Phosphoserine
    1342-1342 Phosphoserine
    1344-1344 Phosphoserine
    1358-1358 Phosphoserine
    1370-1370 Phosphotyrosine
    1375-1375 Phosphoserine
    1400-1400 Phosphoserine
    1403-1403 Phosphothreonine
    1413-1413 Phosphoserine
    1421-1421 Phosphotyrosine
    1424-1424 Phosphoserine
    1441-1441 Phosphoserine
    1452-1452 Phosphoserine
    1454-1454 Phosphoserine
    1461-1461 Phosphoserine
    1466-1466 Phosphoserine
    1473-1473 Phosphoserine
    1476-1476 Phosphoserine
    1522-1522 Phosphoserine
    1524-1524 Phosphoserine
    1526-1526 Phosphoserine
    1550-1550 Phosphoserine
    1552-1552 Phosphoserine
    1575-1575 Phosphothreonine
    1576-1576 Phosphoserine
    1581-1581 Phosphoserine
    1592-1592 Phosphothreonine
    1596-1596 Phosphoserine
    1609-1609 Phosphotyrosine
    1613-1613 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    3-3 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-54,448-453,1112-1139,1202-1626
Order 55-447,454-1111,1140-1201
ProS 8-29,50-54,1202-1206,1236-1247,1331-1335,1368-1373,1603-1612,1620-1626
AlphaFold
Disorder 1-48,303-303,367-370,448-451,635-635,702-702,1118-1140,1209-1231,1259-1626
Order 49-302,304-366,371-447,452-634,636-701,703-1117,1141-1208,1232-1258
Pfam Hmmer
PF02518 97-245 2.3e-13
PF00204 291-451 1e-53
PF00521 734-1201 1.7e-136
PF08070 1508-1611 1e-59
SEG 5-19 ,1109-1121 ,1129-1142 ,1213-1227 ,1248-1269 ,1299-1311 ,1336-1348 ,1376-1395 ,1531-1549 ,1563-1576
Function
Function in SwissProt
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.