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IID00463
 UniprotQ04721
ProteinNeurogenic locus notch homolog protein 2
GeneNOTCH2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2471
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 414-532 Monomer :
 Evidence X-RAY 5mwb A Reference
       Region 5mwb A 414-414 disorder
       Region 5mwb A 415-532 order
Seq 1423-1594,1617-1677 Monomer :
 Evidence X-RAY 2oo4 B Reference
       Region 2oo4 B 1423-1424 disorder
       Region 2oo4 B 1425-1594 order
       Region 2oo4 B 1617-1672 order
       Region 2oo4 B 1673-1677 disorder
 Evidence X-RAY 2oo4 A Reference
       Region 2oo4 A 1423-1424 disorder
       Region 2oo4 A 1425-1594 order
       Region 2oo4 A 1617-1672 order
       Region 2oo4 A 1673-1677 disorder
Seqphosphorylation
    1716-1716 Phosphothreonine
    1778-1778 Phosphoserine
    1802-1802 Phosphothreonine
    1804-1804 Phosphoserine
    1808-1808 Phosphothreonine
    1842-1842 Phosphoserine
    1845-1845 Phosphoserine
    2070-2070 Phosphoserine
    2078-2078 Phosphoserine
    2081-2081 Phosphoserine
    2097-2097 Phosphothreonine
 
Prediction
NeProc
Disorder 1598-1610,1704-1709,1718-1784,1841-1854,2065-2471
Order 1-1597,1611-1671,1678-1703,1710-1717,1785-1840,1855-2064
ProS 1704-1709,1727-1740,1751-1772,1780-1784,2086-2092,2150-2160,2209-2213,2250-2254,2408-2426,2432-2442,2467-2471
AlphaFold
Disorder 1-30,32-34,45-48,56-56,67-67,69-72,74-76,81-89,93-99,102-114,116-118,121-128,130-130,136-136,139-140,144-145,147-147,149-150,155-156,161-165,167-167,173-173,188-190,194-195,211-212,214-216,220-228,232-233,238-238,240-243,250-251,255-255,259-260,262-262,265-266,272-272,277-280,288-288,297-298,300-300,304-307,311-311,317-317,319-320,328-329,339-340,343-346,349-350,356-357,359-359,365-367,370-371,375-376,378-378,380-382,386-387,393-395,397-398,404-406,409-410,413-415,417-417,420-425,427-428,430-430,435-439,446-447,449-449,451-451,455-458,462-463,467-468,472-477,484-485,494-494,496-497,499-499,501-501,505-506,510-515,517-517,519-519,521-526,531-540,542-545,548-553,555-555,557-566,568-578,580-581,585-590,596-598,600-603,606-610,614-614,618-619,623-628,630-630,634-636,638-639,644-647,650-652,661-665,672-673,678-678,681-685,687-696,698-728,734-742,747-748,751-751,753-753,757-759,762-764,767-769,773-778,782-782,784-786,788-789,794-797,800-802,805-808,812-816,821-829,831-841,843-856,858-858,860-881,883-886,888-894,896-896,898-907,910-913,916-918,921-923,928-932,938-940,943-944,947-949,951-951,954-954,956-956,960-961,966-966,968-970,974-974,976-982,986-1000,1002-1008,1010-1010,1012-1028,1030-1030,1032-1032,1036-1037,1041-1046,1051-1054,1056-1057,1062-1075,1080-1086,1088-1088,1092-1092,1129-1131,1139-1140,1148-1152,1154-1156,1160-1161,1166-1170,1177-1178,1185-1185,1187-1187,1189-1189,1192-1195,1197-1201,1203-1208,1210-1210,1212-1239,1242-1249,1251-1255,1257-1260,1262-1266,1268-1271,1275-1277,1279-1280,1282-1287,1291-1298,1302-1309,1311-1312,1314-1316,1321-1330,1332-1340,1342-1386,1389-1397,1399-1399,1404-1406,1408-1409,1412-1429,1431-1431,1434-1437,1447-1447,1467-1470,1475-1480,1495-1502,1504-1504,1584-1584,1594-1617,1619-1619,1635-1637,1658-1658,1670-1688,1690-1821,1825-1827,1838-1857,2064-2471
Order 31-31,35-44,49-55,57-66,68-68,73-73,77-80,90-92,100-101,115-115,119-120,129-129,131-135,137-138,141-143,146-146,148-148,151-154,157-160,166-166,168-172,174-187,191-193,196-210,213-213,217-219,229-231,234-237,239-239,244-249,252-254,256-258,261-261,263-264,267-271,273-276,281-287,289-296,299-299,301-303,308-310,312-316,318-318,321-327,330-338,341-342,347-348,351-355,358-358,360-364,368-369,372-374,377-377,379-379,383-385,388-392,396-396,399-403,407-408,411-412,416-416,418-419,426-426,429-429,431-434,440-445,448-448,450-450,452-454,459-461,464-466,469-471,478-483,486-493,495-495,498-498,500-500,502-504,507-509,516-516,518-518,520-520,527-530,541-541,546-547,554-554,556-556,567-567,579-579,582-584,591-595,599-599,604-605,611-613,615-617,620-622,629-629,631-633,637-637,640-643,648-649,653-660,666-671,674-677,679-680,686-686,697-697,729-733,743-746,749-750,752-752,754-756,760-761,765-766,770-772,779-781,783-783,787-787,790-793,798-799,803-804,809-811,817-820,830-830,842-842,857-857,859-859,882-882,887-887,895-895,897-897,908-909,914-915,919-920,924-927,933-937,941-942,945-946,950-950,952-953,955-955,957-959,962-965,967-967,971-973,975-975,983-985,1001-1001,1009-1009,1011-1011,1029-1029,1031-1031,1033-1035,1038-1040,1047-1050,1055-1055,1058-1061,1076-1079,1087-1087,1089-1091,1093-1128,1132-1138,1141-1147,1153-1153,1157-1159,1162-1165,1171-1176,1179-1184,1186-1186,1188-1188,1190-1191,1196-1196,1202-1202,1209-1209,1211-1211,1240-1241,1250-1250,1256-1256,1261-1261,1267-1267,1272-1274,1278-1278,1281-1281,1288-1290,1299-1301,1310-1310,1313-1313,1317-1320,1331-1331,1341-1341,1387-1388,1398-1398,1400-1403,1407-1407,1410-1411,1430-1430,1432-1433,1438-1446,1448-1466,1471-1474,1481-1494,1503-1503,1505-1583,1585-1593,1618-1618,1620-1634,1638-1657,1659-1669,1689-1689,1822-1824,1828-1837,1858-2063
Pfam Hmmer
PF00008 28-62 0.00025
PF00008 68-101 4.5e-08
PF00008 109-142 4.2e-08
PF00008 148-179 5.1e-07
PF07645 182-218 2.7e-11
PF00008 225-257 1.9e-06
PF00008 264-295 5e-08
PF07645 298-335 6.3e-08
PF00008 379-412 1.1e-06
PF00008 419-453 8.2e-10
PF00008 460-491 2.2e-09
PF00008 498-529 4.7e-10
PF00008 536-567 2.2e-10
PF00008 574-604 2e-07
PF00008 611-642 8e-09
PF00008 649-679 3.8e-10
PF00008 686-717 1.9e-05
PF00008 724-754 3.1e-06
PF00008 761-792 2.9e-08
PF00008 799-830 1.1e-10
PF00008 837-870 1.1e-09
PF07645 873-908 4e-09
PF00008 915-946 1.6e-10
PF00008 953-984 1e-09
PF00008 991-1022 1.3e-09
PF00008 1029-1060 7e-12
PF00008 1067-1098 4.1e-07
PF00008 1116-1146 2.2e-05
PF00008 1153-1184 1.1e-10
PF00008 1191-1222 1.7e-08
PF00008 1229-1261 2.2e-08
PF00008 1308-1342 5.1e-09
PF00008 1378-1411 3e-06
PF00066 1420-1456 3.4e-14
PF00066 1498-1535 4.4e-11
PF06816 1539-1595 2e-33
PF07684 1617-1677 2e-27
PF00023 1827-1874 1.6e-12
PF00023 1876-1908 9.1e-08
PF00023 1943-1975 1.3e-06
PF00023 1976-2008 5.8e-07
PF00023 2009-2041 5.4e-05
SEG 3-26 ,1645-1651 ,1678-1698 ,1771-1782 ,1834-1856 ,2185-2198 ,2417-2438 ,2440-2457
Function
Function in SwissProt
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).