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IID00466
UniprotQ12968
ProteinNuclear factor of activated T-cells, cytoplasmic 3
GeneNFATC3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1075
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 141-154 Hetero dimer : IID00270Complex
 Evidence X-RAY 2xs0 B Reference
       Region 2xs0 B 141-142 disorder
       Region 2xs0 B 143-154 order
 Evidence X-RAY 2xrw B Reference
       Region 2xrw B 141-142 disorder
       Region 2xrw B 143-154 order
SeqProS predicted 143-154 The unbound state of this region is deduced to be disordered based on the results of prediction tools (DICHOT, Mobi, d2p2 etc). Hetero dimer : IID00270Complex
       Region 2xs0 B 143-154 order
       Region 2xrw B 143-154 order
Seqphosphorylation
    1066-1066 Phosphoserine
    1063-1063 Phosphoserine
    372-372 Phosphoserine
    344-344 Phosphoserine
Seqacetylation
    2-2 N-acetylthreonine
 
Prediction
NeProc
Disorder 1-460,706-1075
Order 461-593,599-705
ProS 1-24,37-38,49-65,81-92,105-121,128-133,144-161,176-191,203-217,251-257,274-280,294-309,328-333,339-345,375-402,422-437,449-460,706-711,1008-1015,1020-1047,1052-1075
AlphaFold
Disorder 1-195,200-408,552-559,594-598,702-1031,1045-1075
Order 196-199,409-551,560-593,599-701,1032-1044
Pfam Hmmer
PF00554 433-592 1.3e-52
PF01833 600-698 8.7e-18
SEG 22-30 ,51-68 ,152-181 ,204-221 ,256-270 ,285-304 ,712-721 ,916-967
Function
Function in SwissProt
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Along with NFATC4, involved in embryonic heart development (By similarity).
Biological Process
Diagram with PDB data
NEATC3/MAPK8Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4