IDEAL List

IDEAL

IID00471
UniprotQ13568
ProteinInterferon regulatory factor 5
GeneIRF5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

498

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 232-477 Homo dimer :

Evidence X-RAY 3dsh A Reference

Region 3dsh A 232-467 order

Region 3dsh A 468-477 disorder

Seqphosphorylation

437-437 Phosphoserine

10-10 Phosphothreonine

158-158 Phosphoserine; by TBK1

293-293 Phosphoserine; by TBK1

301-301 Phosphoserine

431-431 Phosphoserine

435-435 Phosphoserine

440-440 Phosphoserine

446-446 Phosphoserine; by IKKB

Prediction

NeProc

Disorder 1-14,76-79,102-105,125-245,284-303,349-356,438-498

Order 15-75,80-101,106-124,246-278,304-348,357-437

ProS 76-79,102-105,131-139,182-200,205-211,223-241,284-303,438-447,454-468,477-498

AlphaFold

Disorder 1-14,50-60,106-113,123-244,354-355,432-444,446-446,470-498

Order 15-49,61-105,114-122,245-353,356-431,445-445,447-469

Pfam Hmmer

PF00605 14-123 6.5e-46

SEG 142-149 ,166-209 ,219-232

Function

Function in SwissProt

Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).