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IID00473
 UniprotQ14192
ProteinFour and a half LIM domains protein 2
GeneFHL2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
279
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-98 Monomer :
 Evidence NMR 2miu A Reference
       Region 2miu A 1-98 order
Seq 101-159 Monomer :
 Evidence NMR 1x4k A Reference
       Region 1x4k A 101-159 order
Seq 162-218 Monomer :
 Evidence NMR 2d8z A Reference
       Region 2d8z A 162-218 order
Seq 221-279 Monomer :
 Evidence NMR 1x4l A Reference
       Region 1x4l A 221-279 order
       Region 1x4l A 231-231 high_rmsd
Seqphosphorylation
    238-238 Phosphoserine
 
Prediction
NeProc
Order 1-279
AlphaFold
Disorder 1-2,231-234
Order 3-230,235-279
Pfam Hmmer
PF00412 40-98 1e-06
PF00412 101-159 2.4e-11
PF00412 162-218 3.8e-14
PF00412 221-275 3.4e-05
Function
Function in SwissProt
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).