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IID00476
 UniprotQ15678
ProteinTyrosine-protein phosphatase non-receptor type 14
GenePTPN14
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1187
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 886-1187 Monomer :
 Evidence X-RAY 2bzl A Reference
       Region 2bzl A 886-894 disorder
       Region 2bzl A 895-904 order
       Region 2bzl A 905-907 disorder
       Region 2bzl A 908-1025 order
       Region 2bzl A 1026-1028 disorder
       Region 2bzl A 1029-1184 order
       Region 2bzl A 1185-1187 disorder
Seqphosphorylation
    642-642 Phosphoserine
    594-594 Phosphoserine
    593-593 Phosphoserine
    591-591 Phosphoserine
    486-486 Phosphoserine
    461-461 Phosphoserine
    314-314 Phosphoserine
    831-831 Phosphoserine
 
Prediction
NeProc
Disorder 1-15,307-562,567-864,869-891,1106-1111
Order 16-306,563-566,865-868,892-1105,1112-1187
ProS 1-15,316-351,357-370,376-397,434-442,450-455,473-485,502-510,533-547,554-562,567-572,578-582,587-608,621-627,639-671,701-707,718-725,742-757,769-864,869-881
AlphaFold
Disorder 1-18,246-248,307-446,448-894,1108-1112,1185-1187
Order 19-245,249-306,447-447,895-1107,1113-1184
Pfam Hmmer
PF00373 23-220 6e-38
PF00102 933-1179 1.6e-110
SEG 172-182 ,565-575 ,707-720 ,815-832
Function
Function in SwissProt
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.