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IID00477
 UniprotQ16621
ProteinTranscription factor NF-E2 45 kDa subunit
GeneNFE2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
373
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 214-293 Monomer :
 Evidence NMR 2kz5 A Reference
       Region 2kz5 A 214-293 order
       Region 2kz5 A 214-220 high_rmsd
       Region 2kz5 A 284-293 high_rmsd
Seqphosphorylation
    157-157 Phosphoserine; by MAPK8
    170-170 Phosphoserine; by PKA
 
Prediction
NeProc
Disorder 1-225,366-373
Order 226-365
ProS 21-50,64-75,83-102,114-133,139-164,170-181,212-225,370-373
AlphaFold
Disorder 1-21,34-59,61-222,366-373
Order 22-33,60-60,223-365
Pfam Hmmer
PF00170 264-328 1.7e-05
SEG 50-68 ,77-86 ,105-120 ,171-182 ,294-317
Function
Function in SwissProt
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.