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IID00484
 UniprotQ8IYD8
ProteinFanconi anemia group M protein
GeneFANCM
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2048
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 661-800 Hetero pentamer : IID00424Complex,IID00620Complex
 Evidence X-RAY 4e45 O Reference
       Region 4e45 O 667-675 disorder
       Region 4e45 O 676-713 order
       Region 4e45 O 714-724 disorder
       Region 4e45 O 725-771 order
       Region 4e45 O 772-774 disorder
       Region 4e45 O 775-790 order
       Region 4e45 O 791-800 disorder
 Evidence X-RAY 4e45 J Reference
       Region 4e45 J 667-675 disorder
       Region 4e45 J 676-713 order
       Region 4e45 J 714-724 disorder
       Region 4e45 J 725-791 order
       Region 4e45 J 792-800 disorder
 Evidence X-RAY 4e45 E Reference
       Region 4e45 E 667-675 disorder
       Region 4e45 E 676-713 order
       Region 4e45 E 714-724 disorder
       Region 4e45 E 725-791 order
       Region 4e45 E 792-800 disorder
 Evidence X-RAY 4drb I Reference
       Region 4drb I 661-675 disorder
       Region 4drb I 676-713 order
       Region 4drb I 714-724 disorder
       Region 4drb I 725-771 order
       Region 4drb I 772-773 disorder
       Region 4drb I 774-791 order
       Region 4drb I 792-800 disorder
 Evidence X-RAY 4drb F Reference
       Region 4drb F 661-674 disorder
       Region 4drb F 675-712 order
       Region 4drb F 713-724 disorder
       Region 4drb F 725-771 order
       Region 4drb F 772-774 disorder
       Region 4drb F 775-789 order
       Region 4drb F 790-800 disorder
 Evidence X-RAY 4drb C Reference
       Region 4drb C 661-674 disorder
       Region 4drb C 675-714 order
       Region 4drb C 715-724 disorder
       Region 4drb C 725-790 order
       Region 4drb C 791-800 disorder
Seq 1218-1251 Hetero trimer : IID00419Complex,IID00421Complex
 Evidence X-RAY 4day C Reference
       Region 4day C 1218-1225 disorder
       Region 4day C 1226-1237 order
       Region 4day C 1238-1251 disorder
Seq 1798-2048 Hetero dimer : Q9BTP7
 Evidence X-RAY 4bxo A Reference
       Region 4bxo A 1798-1817 disorder
       Region 4bxo A 1818-1902 order
       Region 4bxo A 1903-1912 disorder
       Region 4bxo A 1913-1962 order
       Region 4bxo A 1963-1968 disorder
       Region 4bxo A 1969-2035 order
       Region 4bxo A 2036-2048 disorder
 Evidence X-RAY 4m6w A Reference
       Region 4m6w A 1813-1814 disorder
       Region 4m6w A 1815-1902 order
       Region 4m6w A 1903-1915 disorder
       Region 4m6w A 1916-1964 order
       Region 4m6w A 1965-1969 disorder
       Region 4m6w A 1970-2030 order
       Region 4m6w A 2031-2031 disorder
Seqphosphorylation
    1674-1674 Phosphoserine
    1673-1673 Phosphoserine
    34-34 Phosphoserine
 
Prediction
NeProc
Disorder 1-69,466-474,516-520,576-580,650-707,777-1556,1595-1814,2039-2048
Order 70-435,441-465,475-515,521-575,581-649,708-776,1557-1594,1815-2038
ProS 1-13,36-42,52-58,516-520,576-580,664-707,777-790,799-801,819-823,831-853,860-865,871-893,903-979,985-995,1000-1008,1020-1037,1055-1156,1171-1199,1206-1239,1270-1276,1281-1306,1318-1326,1342-1364,1369-1387,1394-1402,1419-1426,1431-1441,1447-1464,1472-1527,1537-1556,1599-1609,1622-1651,1664-1683,1692-1699,1733-1752,1770-1774,2039-2048
AlphaFold
Disorder 1-72,323-324,423-441,468-474,512-518,548-549,615-617,649-680,692-740,747-747,749-749,768-768,771-775,777-778,785-1562,1564-1817,1903-1912,2029-2048
Order 73-322,325-422,442-467,475-511,519-547,550-614,618-648,681-691,741-746,748-748,750-767,769-770,776-776,779-784,1563-1563,1818-1902,1913-2028
Pfam Hmmer
PF00270 92-255 1e-17
PF00271 497-581 4.1e-21
PF02732 1819-1902 9.9e-07
SEG 40-51 ,351-360 ,849-863 ,994-1007 ,1512-1524 ,1527-1544
Function
Function in SwissProt
DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434).
Biological Process
Diagram with PDB data
FANCM/CENPS/CENPXThe crystal structure of FANCM bound MHF complex
FANCM/RMI1/RMI2Crystal structure of the RMI core complex with MM2 peptide from FANCM