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IID00487
 UniprotQ8NB78
ProteinLysine-specific histone demethylase 1B
GeneKDM1B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
822
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 30-822 Hetero dimer : IID00062Complex
 Evidence X-RAY 4fwf A Reference
       Region 4fwf A 30-49 disorder
       Region 4fwf A 50-74 order
       Region 4fwf A 75-75 disorder
       Region 4fwf A 76-173 order
       Region 4fwf A 174-183 disorder
       Region 4fwf A 184-237 order
       Region 4fwf A 238-260 disorder
       Region 4fwf A 261-822 order
Seq 30-822 Monomer :
 Evidence X-RAY 4gu1 B Reference
       Region 4gu1 B 51-172 order
       Region 4gu1 B 173-180 disorder
       Region 4gu1 B 181-234 order
       Region 4gu1 B 235-263 disorder
       Region 4gu1 B 264-821 order
       Region 4gu1 B 822-822 disorder
 Evidence X-RAY 4gu1 A Reference
       Region 4gu1 A 51-172 order
       Region 4gu1 A 173-180 disorder
       Region 4gu1 A 181-234 order
       Region 4gu1 A 235-263 disorder
       Region 4gu1 A 264-821 order
       Region 4gu1 A 822-822 disorder
 Evidence X-RAY 4fwj B Reference
       Region 4fwj B 30-50 disorder
       Region 4fwj B 51-104 order
       Region 4fwj B 105-105 disorder
       Region 4fwj B 106-174 order
       Region 4fwj B 175-179 disorder
       Region 4fwj B 180-237 order
       Region 4fwj B 238-261 disorder
       Region 4fwj B 262-822 order
 Evidence X-RAY 4fwj A Reference
       Region 4fwj A 30-47 disorder
       Region 4fwj A 48-176 order
       Region 4fwj A 177-177 disorder
       Region 4fwj A 178-237 order
       Region 4fwj A 238-261 disorder
       Region 4fwj A 262-822 order
 Evidence X-RAY 4fwe A Reference
       Region 4fwe A 30-48 disorder
       Region 4fwe A 49-175 order
       Region 4fwe A 176-177 disorder
       Region 4fwe A 178-237 order
       Region 4fwe A 238-259 disorder
       Region 4fwe A 260-822 order
Seq 51-822 Hetero trimer : IID00239Complex,Q49A26
 Evidence X-RAY 4gus A Reference
       Region 4gus A 51-235 order
       Region 4gus A 236-263 disorder
       Region 4gus A 264-822 order
 Evidence X-RAY 4gur A Reference
       Region 4gur A 51-171 order
       Region 4gur A 172-181 disorder
       Region 4gur A 182-235 order
       Region 4gur A 236-263 disorder
       Region 4gur A 264-822 order
Seq 51-822 Hetero trimer : IID00239Complex
 Evidence X-RAY 4gu0 D Reference
       Region 4gu0 D 51-171 order
       Region 4gu0 D 172-182 disorder
       Region 4gu0 D 183-235 order
       Region 4gu0 D 236-263 disorder
       Region 4gu0 D 264-822 order
 Evidence X-RAY 4gu0 B Reference
       Region 4gu0 B 51-235 order
       Region 4gu0 B 236-263 disorder
       Region 4gu0 B 264-822 order
 Evidence X-RAY 4gu0 C Reference
       Region 4gu0 C 51-171 order
       Region 4gu0 C 172-182 disorder
       Region 4gu0 C 183-235 order
       Region 4gu0 C 236-263 disorder
       Region 4gu0 C 264-822 order
 Evidence X-RAY 4gu0 A Reference
       Region 4gu0 A 51-235 order
       Region 4gu0 A 236-263 disorder
       Region 4gu0 A 264-822 order
Seq 51-822 Hetero dimer : Q49A26
 Evidence X-RAY 4guu A Reference
       Region 4guu A 51-174 order
       Region 4guu A 175-181 disorder
       Region 4guu A 182-235 order
       Region 4guu A 236-263 disorder
       Region 4guu A 264-821 order
       Region 4guu A 822-822 disorder
 Evidence X-RAY 4gut A Reference
       Region 4gut A 51-174 order
       Region 4gut A 175-181 disorder
       Region 4gut A 182-235 order
       Region 4gut A 236-263 disorder
       Region 4gut A 264-821 order
       Region 4gut A 822-822 disorder
Seq 51-822 Hetero trimer : Q49A26,Q92133
 Evidence X-RAY 4hsu A Reference
       Region 4hsu A 51-172 order
       Region 4hsu A 173-181 disorder
       Region 4hsu A 182-235 order
       Region 4hsu A 236-263 disorder
       Region 4hsu A 264-822 order
Seqphosphorylation
    13-13 Phosphoserine
    17-17 Phosphoserine
    26-26 Phosphoserine
    247-247 Phosphoserine
 
Prediction
NeProc
Disorder 1-51,233-259
Order 52-232,260-822
ProS 16-23,48-51
AlphaFold
Disorder 1-50,174-181,237-261
Order 51-173,182-236,262-822
Pfam Hmmer
PF07496 137-192 1.9e-18
PF01593 392-820 1e-82
SEG 30-43 ,386-398
Function
Function in SwissProt
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.