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IID00489
 UniprotQ92794
ProteinHistone acetyltransferase KAT6A
GeneKAT6A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2004
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 194-323 Monomer :
 Evidence NMR 2ln0 A Reference
       Region 2ln0 A 204-313 order
 Evidence X-RAY 4ljn A Reference
       Region 4ljn A 194-269 order
       Region 4ljn A 270-273 disorder
       Region 4ljn A 274-316 order
       Region 4ljn A 317-323 disorder
Seq 194-323 Hetero dimer : IID00062Complex
 Evidence X-RAY 3v43 A Reference
       Region 3v43 A 204-313 order
 Evidence X-RAY 4llb B Reference
       Region 4llb B 194-312 order
       Region 4llb B 313-323 disorder
 Evidence X-RAY 4llb A Reference
       Region 4llb A 194-312 order
       Region 4llb A 313-323 disorder
 Evidence X-RAY 4lka A Reference
       Region 4lka A 194-315 order
       Region 4lka A 316-323 disorder
 Evidence X-RAY 4lk9 A Reference
       Region 4lk9 A 194-315 order
       Region 4lk9 A 316-323 disorder
Seq 194-323 Hetero dimer : K7EMV3
 Evidence X-RAY 5b78 A Reference
       Region 5b78 A 194-311 order
       Region 5b78 A 312-323 disorder
 Evidence X-RAY 5b77 A Reference
       Region 5b77 A 194-196 disorder
       Region 5b77 A 197-312 order
       Region 5b77 A 313-323 disorder
 Evidence X-RAY 5b76 A Reference
       Region 5b76 A 194-312 order
       Region 5b76 A 313-323 disorder
 Evidence X-RAY 5b75 A Reference
       Region 5b75 A 194-312 order
       Region 5b75 A 313-323 disorder
Seq 497-784 Monomer :
 Evidence X-RAY 2rc4 A Reference
       Region 2rc4 A 501-506 disorder
       Region 2rc4 A 507-738 order
       Region 2rc4 A 739-747 disorder
       Region 2rc4 A 748-779 order
       Region 2rc4 A 780-784 disorder
 Evidence X-RAY 2ozu A Reference
       Region 2ozu A 497-506 disorder
       Region 2ozu A 507-706 order
       Region 2ozu A 707-711 disorder
       Region 2ozu A 712-737 order
       Region 2ozu A 738-746 disorder
       Region 2ozu A 747-762 order
       Region 2ozu A 763-764 disorder
       Region 2ozu A 765-776 order
       Region 2ozu A 777-780 disorder
Seq 533-563 Monomer :
 Evidence NMR 1m36 A Reference
       Region 1m36 A 533-563 order
Seqphosphorylation
    369-369 Phosphothreonine; by PKB/AKT1
    420-420 Phosphoserine
    473-473 Phosphoserine
    787-787 Phosphoserine
    812-812 Phosphoserine
    899-899 Phosphotyrosine
    941-941 Phosphoserine
    954-954 Phosphoserine
    974-974 Phosphoserine
    1089-1089 Phosphoserine
    1090-1090 Phosphoserine
    1113-1113 Phosphoserine
Seqacetylation
    172-172 N6-acetyllysine
    350-350 N6-acetyllysine
    355-355 N6-acetyllysine
    604-604 N6-acetyllysine; by autocatalysis
    815-815 N6-acetyllysine
    1007-1007 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-2,80-91,173-206,314-502,785-2004
Order 3-79,92-172,207-313,503-784
ProS 1-2,314-417,427-439,449-490,495-499,785-788,968-977,1027-1033,1113-1116,1149-1154,1349-1353,1908-1928,1936-1945,1950-1953,1963-1968,1979-1990,1996-2004
AlphaFold
Disorder 1-3,76-96,134-134,136-141,171-191,199-199,272-273,312-320,323-324,327-327,330-482,492-492,495-506,709-709,780-2004
Order 4-75,97-133,135-135,142-170,192-198,200-271,274-311,321-322,325-326,328-329,483-491,493-494,507-708,710-779
Pfam Hmmer
PF00628 208-265 1e-09
PF00628 267-313 3e-12
PF01853 562-749 3.8e-142
SEG 181-195 ,371-379 ,788-810 ,985-1003 ,1011-1029 ,1031-1044 ,1061-1083 ,1098-1118 ,1147-1160 ,1221-1310 ,1312-1321 ,1367-1376 ,1403-1415 ,1481-1503 ,1534-1548 ,1574-1602 ,1607-1623 ,1647-1701 ,1803-1814 ,1951-1959
Function
Function in SwissProt
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.