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IID00493
 UniprotQ969V6
ProteinMKL/myocardin-like protein 1
GeneMRTFA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
931
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 336-396 Monomer :
 Evidence NMR 2kw9 A Reference
       Region 2kw9 A 336-396 order
       Region 2kw9 A 336-340 high_rmsd
       Region 2kw9 A 387-396 high_rmsd
 Evidence NMR 2kvu A Reference
       Region 2kvu A 336-396 order
       Region 2kvu A 336-339 high_rmsd
       Region 2kvu A 386-396 high_rmsd
Seqphosphorylation
    492-492 Phosphoserine
    6-6 Phosphoserine
    124-124 Phosphoserine
    139-139 Phosphoserine
    156-156 Phosphoserine
    859-859 Phosphoserine
    807-807 Phosphoserine
    792-792 Phosphoserine
    695-695 Phosphoserine
    691-691 Phosphoserine
    685-685 Phosphoserine
    511-511 Phosphoserine
    507-507 Phosphoserine
    305-305 Phosphothreonine
    482-482 Phosphoserine
    458-458 Phosphoserine
    456-456 Phosphothreonine
    454-454 Phosphoserine
    450-450 Phosphothreonine
    449-449 Phosphoserine
    447-447 Phosphothreonine
    446-446 Phosphoserine
    385-385 Phosphoserine
    333-333 Phosphoserine
    320-320 Phosphoserine
    317-317 Phosphoserine
    313-313 Phosphothreonine
    312-312 Phosphoserine
    310-310 Phosphoserine
 
Prediction
NeProc
Disorder 1-522,562-911,917-920,928-931
Order 523-561,912-916,921-927
ProS 1-49,62-114,117-124,750-755,808-816,838-853,864-868,877-895,917-920,928-931
AlphaFold
Disorder 94-96,98-99,102-234,236-236,244-256,280-341,385-520,562-660,662-662,664-664,666-744,765-814,818-819,821-838,849-931
Order 1-93,97-97,100-101,235-235,237-243,257-279,342-384,521-561,661-661,663-663,665-665,745-764,815-817,820-820,839-848
Pfam Hmmer
PF02755 24-49 0.001
PF02755 68-93 0.00083
PF02037 347-381 9.3e-14
SEG 111-124 ,180-190 ,224-237 ,263-281 ,310-320 ,418-442 ,445-458 ,561-570 ,638-647 ,678-703 ,784-812
Function
Function in SwissProt
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.