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IID00495
 UniprotQ99933
ProteinBAG family molecular chaperone regulator 1
GeneBAG1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
345
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 144-222 Monomer :
 Evidence NMR 1wxv A Reference
       Region 1wxv A 144-222 order
Seq 222-334 Hetero hexamer : IID00440Complex
 Evidence X-RAY 5aqo B Reference
       Region 5aqo B 222-331 order
       Region 5aqo B 332-334 disorder
 Evidence X-RAY 5aqo D Reference
       Region 5aqo D 222-331 order
       Region 5aqo D 332-334 disorder
 Evidence X-RAY 5aqo F Reference
       Region 5aqo F 222-331 order
       Region 5aqo F 332-334 disorder
Seq 222-334 Hetero dimer : P19120
 Evidence X-RAY 1hx1 B Reference
       Region 1hx1 B 222-332 order
       Region 1hx1 B 333-334 disorder
Seq 222-334 Hetero dimer : IID00440Complex
 Evidence X-RAY 3fzf B Reference
       Region 3fzf B 222-331 order
       Region 3fzf B 332-334 disorder
 Evidence X-RAY 3fzh B Reference
       Region 3fzh B 222-331 order
       Region 3fzh B 332-334 disorder
 Evidence X-RAY 3fzk B Reference
       Region 3fzk B 222-331 order
       Region 3fzk B 332-334 disorder
 Evidence X-RAY 3fzl B Reference
       Region 3fzl B 222-331 order
       Region 3fzl B 332-334 disorder
 Evidence X-RAY 3fzm B Reference
       Region 3fzm B 222-331 order
       Region 3fzm B 332-334 disorder
 Evidence X-RAY 3ldq B Reference
       Region 3ldq B 222-331 order
       Region 3ldq B 332-334 disorder
 Evidence X-RAY 3m3z B Reference
       Region 3m3z B 222-331 order
       Region 3m3z B 332-334 disorder
 Evidence X-RAY 5aqf B Reference
       Region 5aqf B 222-332 order
       Region 5aqf B 333-334 disorder
 Evidence X-RAY 5aqf D Reference
       Region 5aqf D 222-331 order
       Region 5aqf D 332-334 disorder
 Evidence X-RAY 5aqg B Reference
       Region 5aqg B 222-332 order
       Region 5aqg B 333-334 disorder
 Evidence X-RAY 5aqg D Reference
       Region 5aqg D 222-331 order
       Region 5aqg D 332-334 disorder
 Evidence X-RAY 5aqg F Reference
       Region 5aqg F 222-331 order
       Region 5aqg F 332-334 disorder
 Evidence X-RAY 5aqh B Reference
       Region 5aqh B 222-261 order
       Region 5aqh B 262-263 disorder
       Region 5aqh B 264-332 order
       Region 5aqh B 333-334 disorder
 Evidence X-RAY 5aqi B Reference
       Region 5aqi B 222-332 order
       Region 5aqi B 333-334 disorder
 Evidence X-RAY 5aqi D Reference
       Region 5aqi D 222-331 order
       Region 5aqi D 332-334 disorder
 Evidence X-RAY 5aqj B Reference
       Region 5aqj B 222-331 order
       Region 5aqj B 332-334 disorder
 Evidence X-RAY 5aqj D Reference
       Region 5aqj D 222-331 order
       Region 5aqj D 332-334 disorder
 Evidence X-RAY 5aqj F Reference
       Region 5aqj F 222-331 order
       Region 5aqj F 332-334 disorder
 Evidence X-RAY 5aqk B Reference
       Region 5aqk B 222-330 order
       Region 5aqk B 331-334 disorder
 Evidence X-RAY 5aql B Reference
       Region 5aql B 222-331 order
       Region 5aql B 332-334 disorder
 Evidence X-RAY 5aql D Reference
       Region 5aql D 222-331 order
       Region 5aql D 332-334 disorder
 Evidence X-RAY 5aqm B Reference
       Region 5aqm B 222-331 order
       Region 5aqm B 332-334 disorder
 Evidence X-RAY 5aqm D Reference
       Region 5aqm D 222-331 order
       Region 5aqm D 332-334 disorder
 Evidence X-RAY 5aqp B Reference
       Region 5aqp B 222-331 order
       Region 5aqp B 332-334 disorder
 Evidence X-RAY 5aqp D Reference
       Region 5aqp D 222-330 order
       Region 5aqp D 331-334 disorder
 Evidence X-RAY 5aqp F Reference
       Region 5aqp F 222-330 order
       Region 5aqp F 331-334 disorder
 Evidence X-RAY 5aqq B Reference
       Region 5aqq B 222-261 order
       Region 5aqq B 262-266 disorder
       Region 5aqq B 267-331 order
       Region 5aqq B 332-334 disorder
 Evidence X-RAY 5aqq D Reference
       Region 5aqq D 222-262 order
       Region 5aqq D 263-266 disorder
       Region 5aqq D 267-332 order
       Region 5aqq D 333-334 disorder
 Evidence X-RAY 5aqq F Reference
       Region 5aqq F 222-259 order
       Region 5aqq F 260-267 disorder
       Region 5aqq F 268-332 order
       Region 5aqq F 333-334 disorder
 Evidence X-RAY 5aqr B Reference
       Region 5aqr B 222-331 order
       Region 5aqr B 332-334 disorder
 Evidence X-RAY 5aqr D Reference
       Region 5aqr D 222-332 order
       Region 5aqr D 333-334 disorder
 Evidence X-RAY 5aqr F Reference
       Region 5aqr F 222-332 order
       Region 5aqr F 333-334 disorder
 Evidence X-RAY 5aqs B Reference
       Region 5aqs B 222-331 order
       Region 5aqs B 332-334 disorder
 Evidence X-RAY 5aqs D Reference
       Region 5aqs D 222-331 order
       Region 5aqs D 332-334 disorder
 Evidence X-RAY 5aqt B Reference
       Region 5aqt B 222-331 order
       Region 5aqt B 332-334 disorder
 Evidence X-RAY 5aqu B Reference
       Region 5aqu B 222-331 order
       Region 5aqu B 332-334 disorder
 Evidence X-RAY 5aqv B Reference
       Region 5aqv B 222-331 order
       Region 5aqv B 332-334 disorder
Seq 222-334 Hetero hexamer : IID00440Complex
 Evidence X-RAY 5aqn B Reference
       Region 5aqn B 222-331 order
       Region 5aqn B 332-334 disorder
 Evidence X-RAY 5aqn D Reference
       Region 5aqn D 222-331 order
       Region 5aqn D 332-334 disorder
 Evidence X-RAY 5aqn F Reference
       Region 5aqn F 222-331 order
       Region 5aqn F 332-334 disorder
Seqphosphorylation
    223-223 Phosphoserine
 
Prediction
NeProc
Disorder 1-141
Order 142-162,167-345
ProS 1-27,53-58,66-71
AlphaFold
Disorder 1-143,151-151,159-168,180-180,182-187,198-201,203-207,219-227,260-260,298-301,339-345
Order 144-150,152-158,169-179,181-181,188-197,202-202,208-218,228-259,261-297,302-338
Pfam Hmmer
PF02179 246-326 7.3e-23
SEG 35-54 ,58-71 ,76-115 ,121-138 ,226-242
Function
Function in SwissProt
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).