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IID00496
 UniprotQ9BZ95
ProteinHistone-lysine N-methyltransferase NSD3
GeneNSD3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1437
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 152-163 Hetero dimer : IID00111Complex
 Evidence NMR 2ncz B Reference
       Region 2ncz B 152-163 order
       Region 2ncz B 163-163 high_rmsd
Seq 593-605 Hetero dimer : IID00111Complex
 Evidence NMR 2nd1 B Reference
       Region 2nd1 B 593-605 order
       Region 2nd1 B 605-605 high_rmsd
Seq 953-1064 Monomer :
 Evidence NMR 2daq A Reference
       Region 2daq A 957-1053 order
       Region 2daq A 1029-1033 high_rmsd
 Evidence X-RAY 4rxj A Reference
       Region 4rxj A 953-956 disorder
       Region 4rxj A 957-1064 order
Seq 1054-1285 Monomer :
 Evidence X-RAY 5upd A Reference
       Region 5upd A 1054-1068 disorder
       Region 5upd A 1069-1263 order
       Region 5upd A 1264-1266 disorder
       Region 5upd A 1267-1285 order
Seq 1310-1413 Monomer :
 Evidence X-RAY 4gnd A Reference
       Region 4gnd A 1310-1315 disorder
       Region 4gnd A 1316-1413 order
 Evidence X-RAY 4gnd C Reference
       Region 4gnd C 1310-1413 order
Seq 1310-1413 Hetero dimer : IID00239Complex
 Evidence X-RAY 4gne A Reference
       Region 4gne A 1310-1315 disorder
       Region 4gne A 1316-1413 order
 Evidence X-RAY 4gnf A Reference
       Region 4gnf A 1310-1317 disorder
       Region 4gnf A 1318-1413 order
 Evidence X-RAY 4gng A Reference
       Region 4gng A 1310-1318 disorder
       Region 4gng A 1319-1413 order
 Evidence X-RAY 4gng D Reference
       Region 4gng D 1310-1316 disorder
       Region 4gng D 1317-1413 order
SeqProS predicted 593-605 The unbound state of this region is predicted to be disordered by DICHOT and FoldIndex. Hetero dimer : IID00111Complex
       Region 2nd1 B 593-605 order
Seqphosphorylation
    150-150 Phosphoserine
    457-457 Phosphoserine
    585-585 Phosphoserine
    587-587 Phosphoserine
    590-590 Phosphoserine
    655-655 Phosphoserine
Seqacetylation
    790-790 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-263,344-697,853-864,1288-1323,1414-1437
Order 264-343,698-732,737-852,865-1068,1070-1287,1324-1413
ProS 1-59,68-124,143-179,351-397,540-543,671-681,689-697,860-864,1304-1323,1420-1434
AlphaFold
Disorder 1-264,356-362,393-701,737-737,805-808,830-830,851-860,862-862,869-921,944-944,955-956,1021-1032,1066-1067,1262-1270,1285-1285,1287-1319,1415-1437
Order 265-355,363-392,702-736,738-804,809-829,831-850,861-861,863-868,922-943,945-954,957-1020,1033-1065,1068-1261,1271-1284,1286-1286,1320-1414
Pfam Hmmer
PF00855 267-346 5.6e-17
PF00628 703-748 1.9e-08
PF00628 915-955 4.7e-07
PF00855 957-1033 3e-20
PF00856 1139-1268 1e-51
PF00628 1323-1370 5.8e-06
SEG 128-145 ,183-203 ,848-861
Function
Function in SwissProt
Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.