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IID00498
UniprotQ9H5I1
ProteinHistone-lysine N-methyltransferase SUV39H2
GeneSUV39H2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
410
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 112-410 Monomer :
 Evidence X-RAY 2r3a A Reference
       Region 2r3a A 112-123 disorder
       Region 2r3a A 124-184 order
       Region 2r3a A 185-187 disorder
       Region 2r3a A 188-378 order
       Region 2r3a A 379-392 disorder
       Region 2r3a A 393-410 order
Seqphosphorylation
    381-381 Phosphoserine
    384-384 Phosphoserine
    388-388 Phosphoserine
 
Prediction
NeProc
Disorder 1-5,113-117,124-130,381-393,407-410
Order 6-112,118-123,131-380,394-406
ProS 113-117,124-130,386-393,407-410
AlphaFold
Disorder 1-13,107-116,376-394
Order 14-106,117-375,395-410
Pfam Hmmer
PF00385 47-96 1.1e-16
PF05033 144-242 1.1e-40
PF00856 244-379 2.4e-60
SEG 376-386
Function
Function in SwissProt
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.