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IID00499
 UniprotQ9H7E2
ProteinTudor domain-containing protein 3
GeneTDRD3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
651
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-68 Monomer :
 Evidence X-RAY 5gvd A Reference
       Region 5gvd A 1-68 order
 Evidence X-RAY 5gvd B Reference
       Region 5gvd B 1-68 order
Seq 1-68 Hetero dimer : O95985
 Evidence X-RAY 5gve B Reference
       Region 5gve B 1-68 order
Seq 194-243 Monomer :
 Evidence NMR 1wji A Reference
       Region 1wji A 194-243 order
       Region 1wji A 236-243 high_rmsd
Seq 540-615 Hetero trimer :
 Evidence X-RAY 3pnw F Reference
       Region 3pnw F 540-555 disorder
       Region 3pnw F 556-608 order
       Region 3pnw F 609-615 disorder
Seq 540-615 Hetero trimer :
 Evidence X-RAY 3pnw I Reference
       Region 3pnw I 540-553 disorder
       Region 3pnw I 554-608 order
       Region 3pnw I 609-615 disorder
Seq 540-615 Hetero trimer :
 Evidence X-RAY 3pnw L Reference
       Region 3pnw L 540-554 disorder
       Region 3pnw L 555-608 order
       Region 3pnw L 609-615 disorder
Seq 540-615 Hetero trimer :
 Evidence X-RAY 3pnw R Reference
       Region 3pnw R 540-547 disorder
       Region 3pnw R 548-608 order
       Region 3pnw R 609-615 disorder
Seq 540-615 Hetero trimer :
 Evidence X-RAY 3pnw U Reference
       Region 3pnw U 540-554 disorder
       Region 3pnw U 555-608 order
       Region 3pnw U 609-615 disorder
Seq 540-615 Hetero trimer :
 Evidence X-RAY 3pnw C Reference
       Region 3pnw C 540-548 disorder
       Region 3pnw C 549-608 order
       Region 3pnw C 609-615 disorder
Seq 540-615 Hetero trimer :
 Evidence X-RAY 3pnw X Reference
       Region 3pnw X 540-554 disorder
       Region 3pnw X 555-607 order
       Region 3pnw X 608-615 disorder
Seq 540-615 Hetero trimer :
 Evidence X-RAY 3pnw O Reference
       Region 3pnw O 540-547 disorder
       Region 3pnw O 548-608 order
       Region 3pnw O 609-615 disorder
Seq 553-611 Monomer :
 Evidence X-RAY 3pmt A Reference
       Region 3pmt A 553-553 disorder
       Region 3pmt A 554-608 order
       Region 3pmt A 609-611 disorder
 Evidence X-RAY 3s6w A Reference
       Region 3s6w A 555-580 order
       Region 3s6w A 581-582 disorder
       Region 3s6w A 583-608 order
Seq 554-608 Hetero dimer : IID00126Complex
 Evidence NMR 2lto A Reference
       Region 2lto A 554-608 order
       Region 2lto A 582-583 high_rmsd
Seqphosphorylation
    345-345 Phosphoserine
    256-256 Phosphoserine
 
Prediction
NeProc
Disorder 81-549,612-651
Order 1-80,550-611
ProS 87-122,143-175,184-236,246-256,265-291,298-318,328-341,348-358,367-391,401-425,433-508,513-537,612-633,641-651
AlphaFold
Disorder 75-88,91-91,98-110,112-127,144-192,234-269,281-554,610-646,648-651
Order 1-74,89-90,92-97,111-111,128-143,193-233,270-280,555-609,647-647
Pfam Hmmer
PF00627 194-233 8.5e-11
SEG 151-156 ,241-255
Function
Function in SwissProt
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.