Search Keyword:


Search option:


IID00501
 UniprotQ9HCU9
ProteinBreast cancer metastasis-suppressor 1
GeneBRMS1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
246
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 51-84 Homo octamer :
 Evidence X-RAY 4auv A Reference
       Region 4auv A 51-84 order
 Evidence X-RAY 4auv B Reference
       Region 4auv B 51-57 disorder
       Region 4auv B 58-84 order
 Evidence X-RAY 4auv C Reference
       Region 4auv C 51-84 order
 Evidence X-RAY 4auv D Reference
       Region 4auv D 51-57 disorder
       Region 4auv D 58-75 order
       Region 4auv D 76-84 disorder
 Evidence X-RAY 4auv E Reference
       Region 4auv E 51-56 disorder
       Region 4auv E 57-77 order
       Region 4auv E 78-84 disorder
 Evidence X-RAY 4auv F Reference
       Region 4auv F 51-53 disorder
       Region 4auv F 54-76 order
       Region 4auv F 77-84 disorder
 Evidence X-RAY 4auv G Reference
       Region 4auv G 51-57 disorder
       Region 4auv G 58-84 order
 Evidence X-RAY 4auv H Reference
       Region 4auv H 51-57 disorder
       Region 4auv H 58-79 order
       Region 4auv H 80-84 disorder
Seq 51-98 Homo dimer :
 Evidence X-RAY 2xus A Reference
       Region 2xus A 51-53 disorder
       Region 2xus A 54-94 order
       Region 2xus A 95-98 disorder
 Evidence X-RAY 2xus B Reference
       Region 2xus B 51-90 order
       Region 2xus B 91-98 disorder
 
Prediction
NeProc
Disorder 1-49,180-205,234-246
Order 50-179,206-233
ProS 1-6,180-184,192-198
AlphaFold
Disorder 1-4,6-48,179-209,212-212,237-246
Order 5-5,49-178,210-211,213-236
Pfam Hmmer
PF08598 69-110 7.8e-14
SEG 26-59 ,80-92
Function
Function in SwissProt
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.