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IID00502
 UniprotQ9NXA8
ProteinNAD-dependent protein deacylase sirtuin-5, mitochondrial
GeneSIRT5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
310
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 33-302 Monomer :
 Evidence X-RAY 2b4y A This region binds to ADP-ribose. Reference
       Region 2b4y A 34-35 disorder
       Region 2b4y A 36-67 order
       Region 2b4y A 68-74 disorder
       Region 2b4y A 75-302 order
 Evidence X-RAY 2b4y B This region binds to ADP-ribose. Reference
       Region 2b4y B 34-35 disorder
       Region 2b4y B 36-69 order
       Region 2b4y B 70-74 disorder
       Region 2b4y B 75-302 order
 Evidence X-RAY 2b4y C This region binds to ADP-ribose. Reference
       Region 2b4y C 34-35 disorder
       Region 2b4y C 36-71 order
       Region 2b4y C 72-75 disorder
       Region 2b4y C 76-302 order
 Evidence X-RAY 2b4y D This region binds to ADP-ribose. Reference
       Region 2b4y D 34-35 disorder
       Region 2b4y D 36-70 order
       Region 2b4y D 71-75 disorder
       Region 2b4y D 76-302 order
 Evidence X-RAY 4g1c A This region binds to inhibitor (Carba) and substrate (IDH2). Reference
       Region 4g1c A 36-302 order
 Evidence X-RAY 4g1c B This region binds to inhibitor (Carba) and substrate (IDH2). Reference
       Region 4g1c B 36-302 order
 Evidence X-RAY 5bwl A Reference
       Region 5bwl A 33-35 disorder
       Region 5bwl A 36-302 order
 Evidence X-RAY 6eqs A Reference
       Region 6eqs A 34-302 order
 Evidence X-RAY 6eqs B Reference
       Region 6eqs B 34-34 disorder
       Region 6eqs B 35-302 order
 Evidence X-RAY 6eqs C Reference
       Region 6eqs C 34-302 order
 Evidence X-RAY 6eqs D Reference
       Region 6eqs D 34-302 order
Seq 34-302 Homo dimer :
 Evidence X-RAY 2nyr A This region binds to inhibitor (suramin). Reference
       Region 2nyr A 34-35 disorder
       Region 2nyr A 36-277 order
       Region 2nyr A 278-285 disorder
       Region 2nyr A 286-302 order
 Evidence X-RAY 2nyr B This region binds to inhibitor (suramin). Reference
       Region 2nyr B 34-35 disorder
       Region 2nyr B 36-276 order
       Region 2nyr B 277-285 disorder
       Region 2nyr B 286-302 order
 Evidence X-RAY 4hda A This region binds to activator (resveratrol) and substrate (fluor-peptide). Reference
       Region 4hda A 34-34 disorder
       Region 4hda A 35-301 order
       Region 4hda A 302-302 disorder
 Evidence X-RAY 4hda B This region binds to activator (resveratrol) and substrate (fluor-peptide). Reference
       Region 4hda B 34-302 order
Seq 34-302 Hetero dimer : IID00062Complex
 Evidence X-RAY 3rig A Reference
       Region 3rig A 34-61 order
       Region 3rig A 62-73 disorder
       Region 3rig A 74-302 order
 Evidence X-RAY 3rig B Reference
       Region 3rig B 34-59 order
       Region 3rig B 60-72 disorder
       Region 3rig B 73-302 order
 Evidence X-RAY 3riy A Reference
       Region 3riy A 34-302 order
 Evidence X-RAY 3riy B Reference
       Region 3riy B 34-302 order
 Evidence X-RAY 4f4u A Reference
       Region 4f4u A 34-70 order
       Region 4f4u A 71-74 disorder
       Region 4f4u A 75-302 order
 Evidence X-RAY 4f4u B Reference
       Region 4f4u B 34-63 order
       Region 4f4u B 64-74 disorder
       Region 4f4u B 75-302 order
 Evidence X-RAY 4f56 A Reference
       Region 4f56 A 34-35 disorder
       Region 4f56 A 36-302 order
 Evidence X-RAY 4f56 B Reference
       Region 4f56 B 34-302 order
 
Prediction
NeProc
Disorder 1-34,310-310
Order 35-309
ProS 1-21
AlphaFold
Disorder 1-34,71-74,309-310
Order 35-70,75-308
Pfam Hmmer
PF02146 58-256 1.6e-62
Function
Function in SwissProt
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.