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IID00503
 UniprotQ9NZN8
ProteinCCR4-NOT transcription complex subunit 2
GeneCNOT2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
540
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 344-540 Hetero trimer : IID00423Complex,IID00434Complex
 Evidence X-RAY 4c0d B Reference
       Region 4c0d B 344-349 disorder
       Region 4c0d B 350-540 order
Seq 350-540 Hetero hexamer : IID00423Complex,IID00434Complex
 Evidence X-RAY 5fu6 B Reference
       Region 5fu6 B 350-540 order
 Evidence X-RAY 5fu6 E Reference
       Region 5fu6 E 350-540 order
Seq 350-540 Hetero octamer : A0A0B4KGY5,IID00423Complex,IID00434Complex
 Evidence X-RAY 5fu7 B Reference
       Region 5fu7 B 350-539 order
       Region 5fu7 B 540-540 disorder
 Evidence X-RAY 5fu7 F Reference
       Region 5fu7 F 350-539 order
       Region 5fu7 F 540-540 disorder
Seq 429-540 Homo dimer :
 Evidence X-RAY 4c0f A Reference
       Region 4c0f A 429-432 disorder
       Region 4c0f A 433-528 order
       Region 4c0f A 529-540 disorder
 Evidence X-RAY 4c0f B Reference
       Region 4c0f B 429-526 order
       Region 4c0f B 527-540 disorder
 Evidence X-RAY 4c0f C Reference
       Region 4c0f C 429-536 order
       Region 4c0f C 537-540 disorder
 Evidence X-RAY 4c0f D Reference
       Region 4c0f D 429-440 disorder
       Region 4c0f D 441-540 order
SeqProS possible 350-428 This region is described to be disordered in the free state (PubMed=24121232). Hetero octamer : A0A0B4KGY5,IID00423Complex,IID00434Complex
       Region 5fu7 B 350-539 order
       Region 5fu7 F 350-539 order
SeqProS possible 350-428 This region is described to be disordered in the free state (PubMed=24121232). Hetero hexamer : IID00423Complex,IID00434Complex
       Region 5fu6 B 350-540 order
       Region 5fu6 E 350-540 order
SeqProS possible 350-428 This region is described to be disordered in the free state (PubMed=24121232). Hetero trimer : IID00423Complex,IID00434Complex
       Region 4c0d B 350-540 order
Seqphosphorylation
    165-165 Phosphoserine
    93-93 Phosphothreonine
    126-126 Phosphoserine
    157-157 Phosphoserine
    169-169 Phosphoserine
    242-242 Phosphoserine
    274-274 Phosphoserine
 
Prediction
NeProc
Disorder 1-390,531-540
Order 391-530
ProS 1-21,27-32,41-46,336-340,352-364,369-376,384-390,534-540
AlphaFold
Disorder 1-227,232-274,277-279,281-334,341-341,530-532
Order 228-231,275-276,280-280,335-340,342-529,533-540
Pfam Hmmer
PF04153 381-522 1.2e-79
SEG 153-172
Function
Function in SwissProt
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.