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IID00504
 UniprotQ9UIV1
ProteinCCR4-NOT transcription complex subunit 7
GeneCNOT7
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
285
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-285 Hetero dimer : IID00423Complex
 Evidence X-RAY 4gmj B Reference
       Region 4gmj B 1-9 disorder
       Region 4gmj B 10-266 order
       Region 4gmj B 267-273 disorder
       Region 4gmj B 274-280 order
       Region 4gmj B 281-285 disorder
 Evidence X-RAY 4gmj D Reference
       Region 4gmj D 1-10 disorder
       Region 4gmj D 11-262 order
       Region 4gmj D 263-273 disorder
       Region 4gmj D 274-280 order
       Region 4gmj D 281-285 disorder
 Evidence X-RAY 4gmj F Reference
       Region 4gmj F 1-10 disorder
       Region 4gmj F 11-263 order
       Region 4gmj F 264-273 disorder
       Region 4gmj F 274-280 order
       Region 4gmj F 281-285 disorder
Seq 11-262 Hetero dimer : IID00453Complex
 Evidence X-RAY 2d5r A Reference
       Region 2d5r A 11-262 order
 
Prediction
NeProc
Disorder 1-8,269-285
Order 9-268
AlphaFold
Disorder 1-9,265-285
Order 10-264
Pfam Hmmer
PF04857 13-240 1.4e-132
SEG 259-268
Function
Function in SwissProt
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.