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IID00505
 UniprotQ9UPN9
ProteinE3 ubiquitin-protein ligase TRIM33
GeneTRIM33
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1127
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 882-1087 Monomer :
 Evidence X-RAY 3u5m A Reference
       Region 3u5m A 882-884 disorder
       Region 3u5m A 885-943 order
       Region 3u5m A 944-955 disorder
       Region 3u5m A 956-1046 order
       Region 3u5m A 1047-1059 disorder
       Region 3u5m A 1060-1087 order
 Evidence X-RAY 3u5m B Reference
       Region 3u5m B 882-884 disorder
       Region 3u5m B 885-942 order
       Region 3u5m B 943-954 disorder
       Region 3u5m B 955-1046 order
       Region 3u5m B 1047-1059 disorder
       Region 3u5m B 1060-1087 order
 Evidence X-RAY 3u5m C Reference
       Region 3u5m C 882-884 disorder
       Region 3u5m C 885-939 order
       Region 3u5m C 940-954 disorder
       Region 3u5m C 955-1042 order
       Region 3u5m C 1043-1043 disorder
       Region 3u5m C 1044-1046 order
       Region 3u5m C 1047-1059 disorder
       Region 3u5m C 1060-1087 order
 Evidence X-RAY 3u5m D Reference
       Region 3u5m D 882-884 disorder
       Region 3u5m D 885-942 order
       Region 3u5m D 943-955 disorder
       Region 3u5m D 956-1046 order
       Region 3u5m D 1047-1059 disorder
       Region 3u5m D 1060-1087 order
 Evidence X-RAY 3u5m E Reference
       Region 3u5m E 882-884 disorder
       Region 3u5m E 885-938 order
       Region 3u5m E 939-955 disorder
       Region 3u5m E 956-1046 order
       Region 3u5m E 1047-1059 disorder
       Region 3u5m E 1060-1087 order
 Evidence X-RAY 3u5m F Reference
       Region 3u5m F 882-885 disorder
       Region 3u5m F 886-943 order
       Region 3u5m F 944-954 disorder
       Region 3u5m F 955-1046 order
       Region 3u5m F 1047-1058 disorder
       Region 3u5m F 1059-1087 order
 Evidence X-RAY 3u5m G Reference
       Region 3u5m G 882-884 disorder
       Region 3u5m G 885-943 order
       Region 3u5m G 944-954 disorder
       Region 3u5m G 955-1046 order
       Region 3u5m G 1047-1058 disorder
       Region 3u5m G 1059-1087 order
 Evidence X-RAY 3u5m H Reference
       Region 3u5m H 882-885 disorder
       Region 3u5m H 886-943 order
       Region 3u5m H 944-954 disorder
       Region 3u5m H 955-1046 order
       Region 3u5m H 1047-1059 disorder
       Region 3u5m H 1060-1087 order
 Evidence X-RAY 3u5m I Reference
       Region 3u5m I 882-885 disorder
       Region 3u5m I 886-938 order
       Region 3u5m I 939-954 disorder
       Region 3u5m I 955-1046 order
       Region 3u5m I 1047-1059 disorder
       Region 3u5m I 1060-1087 order
 Evidence X-RAY 3u5m J Reference
       Region 3u5m J 882-884 disorder
       Region 3u5m J 885-938 order
       Region 3u5m J 939-954 disorder
       Region 3u5m J 955-1046 order
       Region 3u5m J 1047-1059 disorder
       Region 3u5m J 1060-1087 order
 Evidence X-RAY 3u5m K Reference
       Region 3u5m K 882-884 disorder
       Region 3u5m K 885-939 order
       Region 3u5m K 940-954 disorder
       Region 3u5m K 955-1046 order
       Region 3u5m K 1047-1059 disorder
       Region 3u5m K 1060-1087 order
 Evidence X-RAY 3u5m L Reference
       Region 3u5m L 882-885 disorder
       Region 3u5m L 886-939 order
       Region 3u5m L 940-954 disorder
       Region 3u5m L 955-1046 order
       Region 3u5m L 1047-1058 disorder
       Region 3u5m L 1059-1087 order
Seq 882-1087 Hetero dimer : IID00062Complex
 Evidence X-RAY 3u5n A Reference
       Region 3u5n A 882-882 disorder
       Region 3u5n A 883-944 order
       Region 3u5n A 945-954 disorder
       Region 3u5n A 955-1046 order
       Region 3u5n A 1047-1056 disorder
       Region 3u5n A 1057-1087 order
 Evidence X-RAY 3u5n B Reference
       Region 3u5n B 882-882 disorder
       Region 3u5n B 883-945 order
       Region 3u5n B 946-956 disorder
       Region 3u5n B 957-1049 order
       Region 3u5n B 1050-1057 disorder
       Region 3u5n B 1058-1087 order
 Evidence X-RAY 3u5o A Reference
       Region 3u5o A 882-882 disorder
       Region 3u5o A 883-950 order
       Region 3u5o A 951-956 disorder
       Region 3u5o A 957-1049 order
       Region 3u5o A 1050-1059 disorder
       Region 3u5o A 1060-1087 order
 Evidence X-RAY 3u5o B Reference
       Region 3u5o B 882-882 disorder
       Region 3u5o B 883-951 order
       Region 3u5o B 952-957 disorder
       Region 3u5o B 958-1049 order
       Region 3u5o B 1050-1059 disorder
       Region 3u5o B 1060-1087 order
 Evidence X-RAY 3u5o C Reference
       Region 3u5o C 882-882 disorder
       Region 3u5o C 883-1049 order
       Region 3u5o C 1050-1059 disorder
       Region 3u5o C 1060-1087 order
 Evidence X-RAY 3u5o D Reference
       Region 3u5o D 882-882 disorder
       Region 3u5o D 883-949 order
       Region 3u5o D 950-957 disorder
       Region 3u5o D 958-1049 order
       Region 3u5o D 1050-1059 disorder
       Region 3u5o D 1060-1087 order
 Evidence X-RAY 3u5o E Reference
       Region 3u5o E 882-882 disorder
       Region 3u5o E 883-950 order
       Region 3u5o E 951-957 disorder
       Region 3u5o E 958-1049 order
       Region 3u5o E 1050-1059 disorder
       Region 3u5o E 1060-1087 order
 Evidence X-RAY 3u5o F Reference
       Region 3u5o F 882-882 disorder
       Region 3u5o F 883-950 order
       Region 3u5o F 951-956 disorder
       Region 3u5o F 957-1049 order
       Region 3u5o F 1050-1059 disorder
       Region 3u5o F 1060-1087 order
 Evidence X-RAY 3u5o G Reference
       Region 3u5o G 882-882 disorder
       Region 3u5o G 883-948 order
       Region 3u5o G 949-956 disorder
       Region 3u5o G 957-1049 order
       Region 3u5o G 1050-1059 disorder
       Region 3u5o G 1060-1087 order
 Evidence X-RAY 3u5o H Reference
       Region 3u5o H 882-882 disorder
       Region 3u5o H 883-951 order
       Region 3u5o H 952-955 disorder
       Region 3u5o H 956-1049 order
       Region 3u5o H 1050-1059 disorder
       Region 3u5o H 1060-1087 order
 Evidence X-RAY 3u5p A Reference
       Region 3u5p A 882-883 disorder
       Region 3u5p A 884-950 order
       Region 3u5p A 951-956 disorder
       Region 3u5p A 957-1049 order
       Region 3u5p A 1050-1059 disorder
       Region 3u5p A 1060-1087 order
 Evidence X-RAY 3u5p B Reference
       Region 3u5p B 882-883 disorder
       Region 3u5p B 884-950 order
       Region 3u5p B 951-956 disorder
       Region 3u5p B 957-1049 order
       Region 3u5p B 1050-1059 disorder
       Region 3u5p B 1060-1087 order
 Evidence X-RAY 3u5p C Reference
       Region 3u5p C 882-883 disorder
       Region 3u5p C 884-950 order
       Region 3u5p C 951-956 disorder
       Region 3u5p C 957-1049 order
       Region 3u5p C 1050-1059 disorder
       Region 3u5p C 1060-1087 order
 Evidence X-RAY 3u5p D Reference
       Region 3u5p D 882-883 disorder
       Region 3u5p D 884-950 order
       Region 3u5p D 951-956 disorder
       Region 3u5p D 957-1049 order
       Region 3u5p D 1050-1059 disorder
       Region 3u5p D 1060-1087 order
 Evidence X-RAY 3u5p E Reference
       Region 3u5p E 882-883 disorder
       Region 3u5p E 884-950 order
       Region 3u5p E 951-956 disorder
       Region 3u5p E 957-1049 order
       Region 3u5p E 1050-1059 disorder
       Region 3u5p E 1060-1087 order
 Evidence X-RAY 3u5p F Reference
       Region 3u5p F 882-883 disorder
       Region 3u5p F 884-950 order
       Region 3u5p F 951-956 disorder
       Region 3u5p F 957-1049 order
       Region 3u5p F 1050-1059 disorder
       Region 3u5p F 1060-1087 order
 Evidence X-RAY 3u5p G Reference
       Region 3u5p G 882-883 disorder
       Region 3u5p G 884-950 order
       Region 3u5p G 951-956 disorder
       Region 3u5p G 957-1049 order
       Region 3u5p G 1050-1059 disorder
       Region 3u5p G 1060-1087 order
 Evidence X-RAY 3u5p H Reference
       Region 3u5p H 882-883 disorder
       Region 3u5p H 884-950 order
       Region 3u5p H 951-956 disorder
       Region 3u5p H 957-1049 order
       Region 3u5p H 1050-1059 disorder
       Region 3u5p H 1060-1087 order
Seq 882-1040,1058-1090 Hetero dimer : Q5TEC6
 Evidence X-RAY 5mr8 A Reference
       Region 5mr8 A 882-884 disorder
       Region 5mr8 A 885-1040 order
       Region 5mr8 A 1058-1087 order
       Region 5mr8 A 1088-1090 disorder
Seqphosphorylation
    803-803 Phosphoserine
    815-815 Phosphothreonine
    862-862 Phosphoserine
    1051-1051 Phosphothreonine
    1102-1102 Phosphothreonine
    1105-1105 Phosphoserine
    1119-1119 Phosphoserine
Seqacetylation
    763-763 N6-acetyllysine; alternate
    769-769 N6-acetyllysine; alternate
    793-793 N6-acetyllysine; alternate
    951-951 N6-acetyllysine
    953-953 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-120,163-170,204-216,264-269,481-885,937-956,1091-1127
Order 121-162,171-203,217-263,270-480,886-936,957-1090
ProS 1-7,528-534,648-654,697-706,736-740,770-775,940-944,1091-1091,1108-1127
AlphaFold
Disorder 1-122,134-138,162-174,201-214,261-272,452-454,472-472,479-515,532-883,923-923,943-956,1044-1059,1091-1127
Order 123-133,139-161,175-200,215-260,273-451,455-471,473-478,516-531,884-922,924-942,957-1043,1060-1090
Pfam Hmmer
PF00643 212-259 3.1e-12
PF00643 271-312 1e-14
PF00628 889-934 3.2e-13
PF00439 962-1051 6.5e-19
SEG 6-37 ,44-120 ,324-335 ,526-569 ,637-649 ,718-760 ,807-835 ,875-888
Function
Function in SwissProt
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).