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IID00506
 UniprotQ9Y6X2
ProteinE3 SUMO-protein ligase PIAS3
GenePIAS3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
628
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 112-467 Homo tetramer :
 Evidence X-RAY 4mvt D Reference
       Region 4mvt D 112-125 disorder
       Region 4mvt D 126-147 order
       Region 4mvt D 148-155 disorder
       Region 4mvt D 156-176 order
       Region 4mvt D 177-184 disorder
       Region 4mvt D 185-225 order
       Region 4mvt D 226-235 disorder
       Region 4mvt D 236-264 order
       Region 4mvt D 265-267 disorder
       Region 4mvt D 268-315 order
       Region 4mvt D 316-319 disorder
       Region 4mvt D 320-400 order
       Region 4mvt D 401-401 disorder
       Region 4mvt D 402-408 order
       Region 4mvt D 409-467 disorder
 Evidence X-RAY 4mvt C Reference
       Region 4mvt C 112-125 disorder
       Region 4mvt C 126-147 order
       Region 4mvt C 148-155 disorder
       Region 4mvt C 156-176 order
       Region 4mvt C 177-184 disorder
       Region 4mvt C 185-225 order
       Region 4mvt C 226-236 disorder
       Region 4mvt C 237-264 order
       Region 4mvt C 265-267 disorder
       Region 4mvt C 268-408 order
       Region 4mvt C 409-467 disorder
 Evidence X-RAY 4mvt B Reference
       Region 4mvt B 112-125 disorder
       Region 4mvt B 126-147 order
       Region 4mvt B 148-154 disorder
       Region 4mvt B 155-176 order
       Region 4mvt B 177-184 disorder
       Region 4mvt B 185-225 order
       Region 4mvt B 226-235 disorder
       Region 4mvt B 236-265 order
       Region 4mvt B 266-267 disorder
       Region 4mvt B 268-315 order
       Region 4mvt B 316-319 disorder
       Region 4mvt B 320-400 order
       Region 4mvt B 401-401 disorder
       Region 4mvt B 402-408 order
       Region 4mvt B 409-467 disorder
 Evidence X-RAY 4mvt A Reference
       Region 4mvt A 112-125 disorder
       Region 4mvt A 126-147 order
       Region 4mvt A 148-154 disorder
       Region 4mvt A 155-176 order
       Region 4mvt A 177-184 disorder
       Region 4mvt A 185-225 order
       Region 4mvt A 226-235 disorder
       Region 4mvt A 236-264 order
       Region 4mvt A 265-267 disorder
       Region 4mvt A 268-408 order
       Region 4mvt A 409-467 disorder
 
Prediction
NeProc
Disorder 74-128,411-628
Order 1-73,129-410
ProS 122-128,423-427,443-455,494-509,525-533,568-572,617-628
AlphaFold
Disorder 1-2,48-48,67-125,150-152,178-184,410-445,450-628
Order 3-47,49-66,126-149,153-177,185-409,446-449
Pfam Hmmer
PF02037 11-45 2.6e-06
PF02891 323-375 9.9e-36
SEG 34-46 ,70-109 ,608-617
Function
Function in SwissProt
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).