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IID00507
 UniprotO60239
ProteinSH3 domain-binding protein 5
GeneSH3BP5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
455
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 341-350 Hetero dimer : IID00456Complex
 Evidence X-RAY 4h3b D Reference
       Region 4h3b D 341-350 order
 Evidence X-RAY 4h3b B Reference
       Region 4h3b B 341-350 order
Seqphosphorylation
    351-351 Phosphoserine; by MAPK12 and MAPK9
    375-375 Phosphoserine
    376-376 Phosphoserine
    418-418 Phosphoserine
    421-421 Phosphoserine
 
Prediction
NeProc
Disorder 1-39,257-455
Order 40-256
ProS 36-39,257-275,284-309,352-369,385-402,424-455
AlphaFold
Disorder 1-39,266-455
Order 40-265
Pfam Hmmer
PF05276 37-273 1.2e-156
SEG 23-40 ,320-332 ,403-421
Function
Function in SwissProt
Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.