Search Keyword:


Search option:


IID00509
 UniprotP10747
ProteinT-cell-specific surface glycoprotein CD28
GeneCD28
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
220
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 17-152 Hetero hexamer :
 Evidence X-RAY 1yjd C Reference
       Region 1yjd C 17-18 disorder
       Region 1yjd C 19-136 order
       Region 1yjd C 137-152 disorder
Seq 189-196 Hetero dimer : IID00713Complex
 Evidence X-RAY 5aul B Reference
       Region 5aul B 189-189 disorder
       Region 5aul B 190-195 order
       Region 5aul B 196-196 disorder
Seq 189-196 Hetero dimer : IID00713Complex
 Evidence X-RAY 5gji B Reference
       Region 5gji B 189-196 order
Seq 189-196 Hetero dimer : IID00459Complex
 Evidence X-RAY 3wa4 B Reference
       Region 3wa4 B 189-189 disorder
       Region 3wa4 B 190-195 order
       Region 3wa4 B 196-196 disorder
Seq 189-196 Hetero dimer : O75791
 Evidence X-RAY 5gjh D Reference
       Region 5gjh D 189-196 order
 Evidence X-RAY 5gjh B Reference
       Region 5gjh B 189-196 order
Seqphosphorylation
    191-191 Phosphotyrosine
    189-189 Phosphoserine
    209-209 Phosphotyrosine
 
Prediction
NeProc
Disorder 1-16,139-153,177-181,186-205
Order 17-138,154-176,182-185,206-220
ProS 1-16,139-143,151-153,177-181,186-205
AlphaFold
Disorder 1-18,139-152,187-220
Order 19-138,153-186
Function
Function in SwissProt
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).