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IID00513
 UniprotQ12959
ProteinDisks large homolog 1
GeneDLG1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
904
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-65 Monomer : IID00515Complex,IID00521Complex
 Evidence X-RAY 3lra A Reference
       Region 3lra A 2-65 order
Seq 220-317 Hetero dimer : IID00035Complex
 Evidence X-RAY 3rl7 F Reference
       Region 3rl7 F 220-309 order
       Region 3rl7 F 310-317 disorder
 Evidence X-RAY 3rl7 E Reference
       Region 3rl7 E 220-241 order
       Region 3rl7 E 242-250 disorder
       Region 3rl7 E 251-310 order
       Region 3rl7 E 311-317 disorder
 Evidence X-RAY 3rl7 D Reference
       Region 3rl7 D 220-310 order
       Region 3rl7 D 311-317 disorder
 Evidence X-RAY 3rl7 C Reference
       Region 3rl7 C 220-245 order
       Region 3rl7 C 246-249 disorder
       Region 3rl7 C 250-310 order
       Region 3rl7 C 311-317 disorder
 Evidence X-RAY 3rl7 B Reference
       Region 3rl7 B 220-246 order
       Region 3rl7 B 247-249 disorder
       Region 3rl7 B 250-310 order
       Region 3rl7 B 311-317 disorder
 Evidence X-RAY 3rl7 A Reference
       Region 3rl7 A 220-309 order
       Region 3rl7 A 310-317 disorder
Seq 310-407 Hetero dimer : IID00035Complex
 Evidence X-RAY 4g69 A Reference
       Region 4g69 A 310-406 order
       Region 4g69 A 407-407 disorder
Seq 311-407 Homo dimer :
 Evidence X-RAY 2x7z A Reference
       Region 2x7z A 311-407 order
 Evidence X-RAY 4amh B Reference
       Region 4amh B 315-319 disorder
       Region 4amh B 324-326 disorder
       Region 4amh B 327-405 order
 Evidence X-RAY 4amh A Reference
       Region 4amh A 315-319 disorder
       Region 4amh A 324-325 disorder
       Region 4amh A 326-405 order
Seq 315-410 Hetero hexamer : IID00035Complex
 Evidence X-RAY 3rl8 E Reference
       Region 3rl8 E 315-315 disorder
       Region 3rl8 E 316-405 order
       Region 3rl8 E 406-410 disorder
 Evidence X-RAY 3rl8 D Reference
       Region 3rl8 D 315-315 disorder
       Region 3rl8 D 316-409 order
       Region 3rl8 D 410-410 disorder
 Evidence X-RAY 3rl8 C Reference
       Region 3rl8 C 315-315 disorder
       Region 3rl8 C 316-410 order
 Evidence X-RAY 3rl8 B Reference
       Region 3rl8 B 315-315 disorder
       Region 3rl8 B 316-405 order
       Region 3rl8 B 406-410 disorder
 Evidence X-RAY 3rl8 A Reference
       Region 3rl8 A 315-315 disorder
       Region 3rl8 A 316-409 order
       Region 3rl8 A 410-410 disorder
Seq 318-406 Hetero dimer : IID90014Complex
 Evidence NMR 2m3m A Reference
       Region 2m3m A 318-406 order
Seq 318-406 Hetero dimer :
 Evidence NMR 2oqs A This region binds to HPV-18 E6 protein. Reference
       Region 2oqs A 318-406 order
Seq 457-555 Homo hexamer :
 Evidence X-RAY 1pdr A Reference
       Region 1pdr A 457-459 disorder
       Region 1pdr A 460-555 order
Seq 712-904 Monomer :
 Evidence X-RAY 3w9y A Reference
       Region 3w9y A 712-835 order
       Region 3w9y A 836-853 disorder
       Region 3w9y A 854-904 order
Seqphosphorylation
    579-579 Phosphoserine
    676-676 Phosphoserine
    709-709 Phosphoserine
    115-115 Phosphothreonine
    122-122 Phosphoserine
    138-138 Phosphoserine
    158-158 Phosphoserine
    232-232 Phosphoserine
    399-399 Phosphotyrosine
    568-568 Phosphoserine
    573-573 Phosphoserine
    575-575 Phosphoserine
    598-598 Phosphoserine
    619-619 Phosphoserine
    684-684 Phosphoserine
    687-687 Phosphoserine
    834-834 Phosphoserine
 
Prediction
NeProc
Disorder 70-213,330-336,412-461,561-583,642-692
Order 1-69,214-329,337-411,462-560,584-641,693-904
ProS 70-84,89-116,124-131,136-164,199-213,330-336,456-461,571-575,642-692
AlphaFold
Disorder 1-2,60-218,312-315,343-343,405-461,564-582,657-698
Order 3-59,219-311,316-342,344-404,462-563,583-656,699-904
Pfam Hmmer
PF00595 224-308 6.1e-28
PF00595 319-403 4.1e-27
PF00595 466-544 1.8e-26
PF07653 585-649 1.7e-05
PF00625 747-849 7.8e-61
SEG 85-106 ,166-182 ,528-538 ,567-575
Function
Function in SwissProt
Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497).