Search Keyword:


Search option:


IID00516
 UniprotQ8NEM0
ProteinMicrocephalin
GeneMCPH1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
835
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-105 Monomer :
 Evidence X-RAY 2wt8 D Reference
       Region 2wt8 D 1-3 disorder
       Region 2wt8 D 4-95 order
 Evidence X-RAY 2wt8 C Reference
       Region 2wt8 C 1-3 disorder
       Region 2wt8 C 4-95 order
 Evidence X-RAY 2wt8 B Reference
       Region 2wt8 B 1-95 order
 Evidence X-RAY 2wt8 A Reference
       Region 2wt8 A 1-95 order
 Evidence X-RAY 3pa6 C Reference
       Region 3pa6 C 1-3 disorder
       Region 3pa6 C 4-95 order
       Region 3pa6 C 96-105 disorder
 Evidence X-RAY 3pa6 B Reference
       Region 3pa6 B 1-1 disorder
       Region 3pa6 B 2-97 order
       Region 3pa6 B 98-105 disorder
 Evidence X-RAY 3pa6 A Reference
       Region 3pa6 A 1-1 disorder
       Region 3pa6 A 2-100 order
       Region 3pa6 A 101-105 disorder
 Evidence X-RAY 3ktf C Reference
       Region 3ktf C 1-3 disorder
       Region 3ktf C 4-95 order
       Region 3ktf C 96-101 disorder
 Evidence X-RAY 3ktf B Reference
       Region 3ktf B 1-2 disorder
       Region 3ktf B 3-95 order
       Region 3ktf B 96-101 disorder
 Evidence X-RAY 3ktf A Reference
       Region 3ktf A 1-1 disorder
       Region 3ktf A 2-98 order
       Region 3ktf A 99-101 disorder
Seq 639-835 Hetero dimer : IID00027Complex
 Evidence X-RAY 3u3z A Reference
       Region 3u3z A 640-645 disorder
       Region 3u3z A 646-834 order
       Region 3u3z A 835-835 disorder
 Evidence X-RAY 3szm H Reference
       Region 3szm H 640-644 disorder
       Region 3szm H 645-834 order
       Region 3szm H 835-835 disorder
 Evidence X-RAY 3szm G Reference
       Region 3szm G 640-643 disorder
       Region 3szm G 644-834 order
       Region 3szm G 835-835 disorder
 Evidence X-RAY 3szm F Reference
       Region 3szm F 640-645 disorder
       Region 3szm F 646-834 order
       Region 3szm F 835-835 disorder
 Evidence X-RAY 3szm E Reference
       Region 3szm E 640-645 disorder
       Region 3szm E 646-832 order
       Region 3szm E 833-835 disorder
 Evidence X-RAY 3szm D Reference
       Region 3szm D 640-645 disorder
       Region 3szm D 646-834 order
       Region 3szm D 835-835 disorder
 Evidence X-RAY 3szm C Reference
       Region 3szm C 640-643 disorder
       Region 3szm C 644-834 order
       Region 3szm C 835-835 disorder
 Evidence X-RAY 3szm B Reference
       Region 3szm B 640-645 disorder
       Region 3szm B 646-834 order
       Region 3szm B 835-835 disorder
 Evidence X-RAY 3szm A Reference
       Region 3szm A 640-645 disorder
       Region 3szm A 646-834 order
       Region 3szm A 835-835 disorder
 Evidence X-RAY 3shv B Reference
       Region 3shv B 639-644 disorder
       Region 3shv B 645-834 order
       Region 3shv B 835-835 disorder
 Evidence X-RAY 3shv A Reference
       Region 3shv A 639-644 disorder
       Region 3shv A 645-833 order
       Region 3shv A 834-835 disorder
Seq 639-835 Monomer :
 Evidence X-RAY 3sht C Reference
       Region 3sht C 639-646 disorder
       Region 3sht C 647-832 order
       Region 3sht C 833-835 disorder
 Evidence X-RAY 3sht B Reference
       Region 3sht B 639-646 disorder
       Region 3sht B 647-833 order
       Region 3sht B 834-835 disorder
 Evidence X-RAY 3sht A Reference
       Region 3sht A 639-645 disorder
       Region 3sht A 646-833 order
       Region 3sht A 834-835 disorder
Seq 640-835 Hetero dimer : IID00447Complex
 Evidence X-RAY 3t1n B Reference
       Region 3t1n B 640-644 disorder
       Region 3t1n B 645-834 order
       Region 3t1n B 835-835 disorder
 Evidence X-RAY 3t1n A Reference
       Region 3t1n A 640-643 disorder
       Region 3t1n A 644-834 order
       Region 3t1n A 835-835 disorder
Seqphosphorylation
    279-279 Phosphoserine
    287-287 Phosphoserine
    296-296 Phosphoserine
    333-333 Phosphoserine
    335-335 Phosphothreonine
    548-548 Phosphoserine
 
Prediction
NeProc
Disorder 104-645
Order 1-103,646-835
ProS 120-130,144-188,208-247,254-263,297-311,327-333,354-357,365-370,404-418,441-444,458-473,480-489,505-509,561-576,582-608,616-627
AlphaFold
Disorder 1-2,96-124,127-127,142-173,187-413,415-645,835-835
Order 3-95,125-126,128-141,174-186,414-414,646-834
Pfam Hmmer
PF00533 1-80 5.7e-07
SEG 347-360
Function
Function in SwissProt
Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
Biological Process
See also
Diagram with PDB data
H2AX/MCPH1STRUCTURE OF HUMAN MICROCEPHALIN (MCPH1) TANDEM BRCT DOMAINS IN COMPLEX WITH A GAMMA-H2AX PHOSPHOPEPTIDE
H2AX/MCPH1Structure of human microcephalin (MCPH1) tandem BRCT domains in complex with an H2A.X peptide phosphorylated at Ser139 and Tyr142