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IID00517
 UniprotQ8WY41
ProteinNanos homolog 1
GeneNANOS1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
292
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 40-56 Hetero dimer : IID00423Complex
 Evidence X-RAY 4cqo B Reference
       Region 4cqo B 40-54 order
       Region 4cqo B 55-56 disorder
 Evidence X-RAY 4cqo D Reference
       Region 4cqo D 40-53 order
       Region 4cqo D 54-56 disorder
 
Prediction
NeProc
Disorder 1-52,58-209,269-292
Order 53-57,210-268
ProS 1-7,20-52,98-105,123-131,142-157,280-285
AlphaFold
Disorder 1-44,46-211,270-273,280-286,288-288,290-292
Order 45-45,212-269,274-279,287-287,289-289
Pfam Hmmer
PF05741 214-268 1.4e-36
SEG 5-21 ,68-87 ,90-121 ,157-194 ,197-204 ,271-288
Function
Function in SwissProt
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.