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IID00519
 UniprotQ93034
ProteinCullin-5
GeneCUL5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
780
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 10-386 Hetero tetramer : IID00523Complex,IID50219Complex
 Evidence X-RAY 4jgh D Reference
       Region 4jgh D 10-118 order
       Region 4jgh D 119-128 disorder
       Region 4jgh D 129-386 order
Seq 12-321 Hetero pentamer : P12504,Q15369
 Evidence X-RAY 4n9f x Reference
       Region 4n9f x 12-118 order
       Region 4n9f x 119-132 disorder
       Region 4n9f x 133-319 order
       Region 4n9f x 320-321 disorder
 Evidence X-RAY 4n9f r Reference
       Region 4n9f r 12-118 order
       Region 4n9f r 119-132 disorder
       Region 4n9f r 133-320 order
       Region 4n9f r 321-321 disorder
 Evidence X-RAY 4n9f l Reference
       Region 4n9f l 12-118 order
       Region 4n9f l 119-131 disorder
       Region 4n9f l 132-320 order
       Region 4n9f l 321-321 disorder
 Evidence X-RAY 4n9f f Reference
       Region 4n9f f 12-118 order
       Region 4n9f f 119-132 disorder
       Region 4n9f f 133-320 order
       Region 4n9f f 321-321 disorder
 Evidence X-RAY 4n9f V Reference
       Region 4n9f V 12-118 order
       Region 4n9f V 119-132 disorder
       Region 4n9f V 133-320 order
       Region 4n9f V 321-321 disorder
 Evidence X-RAY 4n9f O Reference
       Region 4n9f O 12-118 order
       Region 4n9f O 119-130 disorder
       Region 4n9f O 131-320 order
       Region 4n9f O 321-321 disorder
 Evidence X-RAY 4n9f I Reference
       Region 4n9f I 12-118 order
       Region 4n9f I 119-132 disorder
       Region 4n9f I 133-320 order
       Region 4n9f I 321-321 disorder
 Evidence X-RAY 4n9f C Reference
       Region 4n9f C 12-118 order
       Region 4n9f C 119-131 disorder
       Region 4n9f C 132-320 order
       Region 4n9f C 321-321 disorder
 Evidence X-RAY 4n9f w Reference
       Region 4n9f w 12-118 order
       Region 4n9f w 119-131 disorder
       Region 4n9f w 132-319 order
       Region 4n9f w 320-321 disorder
 Evidence X-RAY 4n9f 9 Reference
       Region 4n9f 9 12-118 order
       Region 4n9f 9 119-132 disorder
       Region 4n9f 9 133-319 order
       Region 4n9f 9 320-321 disorder
 Evidence X-RAY 4n9f 3 Reference
       Region 4n9f 3 12-118 order
       Region 4n9f 3 119-132 disorder
       Region 4n9f 3 133-319 order
       Region 4n9f 3 320-321 disorder
 Evidence X-RAY 4n9f U Reference
       Region 4n9f U 12-118 order
       Region 4n9f U 119-130 disorder
       Region 4n9f U 131-321 order
Seq 401-780 Hetero dimer : IID00059Complex
 Evidence X-RAY 3dpl C Reference
       Region 3dpl C 401-517 order
       Region 3dpl C 518-519 disorder
       Region 3dpl C 520-780 order
Seq 401-780 Hetero trimer : IID00059Complex,Q15843
 Evidence X-RAY 3dqv D Reference
       Region 3dqv D 401-517 order
       Region 3dqv D 518-519 disorder
       Region 3dqv D 520-780 order
 Evidence X-RAY 3dqv C Reference
       Region 3dqv C 401-515 order
       Region 3dqv C 516-519 disorder
       Region 3dqv C 520-780 order
Seqphosphorylation
    210-210 Phosphothreonine
    34-34 Phosphoserine
 
Prediction
NeProc
Disorder 1-10,654-659,690-703
Order 11-653,660-689,704-780
ProS 699-703
AlphaFold
Disorder 1-12,120-132,382-399,537-541,690-700
Order 13-119,133-381,400-536,542-689,701-780
Pfam Hmmer
PF00888 19-673 2.9e-255
SEG 428-444
Function
Function in SwissProt
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.