IDEAL List

IDEAL

IID00520
UniprotQ9HD26
ProteinGolgi-associated PDZ and coiled-coil motif-containing protein
GeneGOPC
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

462

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 278-371 Monomer :

Evidence NMR 2dc2 A Reference

Region 2dc2 A 278-284 disorder

Region 2dc2 A 285-371 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmq B Reference

Region 4nmq B 284-369 order

Region 4nmq B 370-370 disorder

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmq A Reference

Region 4nmq A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmr A Reference

Region 4nmr A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4jok A Reference

Region 4jok A 284-370 order

Seq 284-370 Hetero dimer : IID90005Complex

Evidence X-RAY 4jop A Reference

Region 4jop A 284-370 order

Evidence X-RAY 4jop B Reference

Region 4jop B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4q6s B Reference

Region 4q6s B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4k6y B Reference

Region 4k6y B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4q6h A Reference

Region 4q6h A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4joh B Reference

Region 4joh B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4k6y A Reference

Region 4k6y A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4k72 A Reference

Region 4k72 A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nms A Reference

Region 4nms A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmp A Reference

Region 4nmp A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4jog B Reference

Region 4jog B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmo A Reference

Region 4nmo A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4k76 C Reference

Region 4k76 C 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4k72 B Reference

Region 4k72 B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmo B Reference

Region 4nmo B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmv A Reference

Region 4nmv A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nms B Reference

Region 4nms B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4k76 A Reference

Region 4k76 A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4joe B Reference

Region 4joe B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4q6s A Reference

Region 4q6s A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4k78 A Reference

Region 4k78 A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4k76 B Reference

Region 4k76 B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4jok B Reference

Region 4jok B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4k76 D Reference

Region 4k76 D 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmr B Reference

Region 4nmr B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4joe A Reference

Region 4joe A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmt B Reference

Region 4nmt B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4e34 B Reference

Region 4e34 B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4joh A Reference

Region 4joh A 284-370 order

Seq 284-370 Hetero dimer : P06463

Evidence X-RAY 4jor A Reference

Region 4jor A 284-370 order

Evidence X-RAY 4jor B Reference

Region 4jor B 284-370 order

Evidence X-RAY 5ic3 A Reference

Region 5ic3 A 284-370 order

Evidence X-RAY 5ic3 B Reference

Region 5ic3 B 284-370 order

Evidence X-RAY 5k4f A Reference

Region 5k4f A 284-370 order

Evidence X-RAY 5k4f B Reference

Region 5k4f B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmv B Reference

Region 4nmv B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmt A Reference

Region 4nmt A 284-370 order

Seq 284-370 Hetero tetramer :

Evidence X-RAY 4e35 A Reference

Region 4e35 A 284-370 order

Evidence X-RAY 4e35 B Reference

Region 4e35 B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4k75 A Reference

Region 4k75 A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4joj B Reference

Region 4joj B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4jog A Reference

Region 4jog A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4jof A Reference

Region 4jof A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4joj A Reference

Region 4joj A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4nmp B Reference

Region 4nmp B 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4e34 A Reference

Region 4e34 A 284-370 order

Seq 284-370 Hetero dimer :

Evidence X-RAY 4jof B Reference

Region 4jof B 284-370 order

Seq 286-370 Hetero dimer : IID00540Complex

Evidence NMR 2lob A Reference

Region 2lob A 286-370 order

Region 2lob A 296-296 high_rmsd

Seqacetylation

2-2 N-acetylserine

Prediction

NeProc

Disorder 1-27,136-154,262-283,378-462

Order 28-135,155-261,284-373

ProS 4-8,136-136,138-149,269-283,378-399,405-411,416-436,446-462

AlphaFold

Disorder 1-28,136-155,158-158,198-200,202-203,205-207,225-226,253-253,255-268,270-282,371-462

Order 29-135,156-157,159-197,201-201,204-204,208-224,227-252,254-254,269-269,283-370

Pfam Hmmer

PF00595 288-368 1.9e-17

SEG 2-29 ,120-134

Function

Function in SwissProt

Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.

Biological Process

See also
Diagram with PDB data
CFTR/GOPC	PDZ Domain of CAL (Cystic Fibrosis Transmembrane Regulator-Associated Ligand)