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IID00522
 UniprotQ9UQC2
ProteinGRB2-associated-binding protein 2
GeneGAB2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
676
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 205-214 Hetero dimer : IID00301Complex
 Evidence X-RAY 6y3s P Reference
       Region 6y3s P 205-206 disorder
       Region 6y3s P 207-211 order
       Region 6y3s P 212-214 disorder
Seq 207-212,387-395 Hetero tetramer : IID00061Complex
 Evidence X-RAY 5ewz C Reference
       Region 5ewz C 387-395 order
 Evidence X-RAY 5ewz D Reference
       Region 5ewz D 207-212 order
Seq 350-358 Hetero dimer : IID00459Complex
 Evidence X-RAY 2w0z B Reference
       Region 2w0z B 350-358 order
Seq 386-398 Hetero dimer : IID00301Complex
 Evidence X-RAY 6y3r P Reference
       Region 6y3r P 387-396 order
       Region 6y3r P 397-398 disorder
 Evidence X-RAY 6zvb P Reference
       Region 6zvb P 386-386 disorder
       Region 6zvb P 387-396 order
       Region 6zvb P 397-398 disorder
 Evidence X-RAY 6zvc P Reference
       Region 6zvc P 386-386 disorder
       Region 6zvc P 387-396 order
       Region 6zvc P 397-398 disorder
 Evidence X-RAY 6zvd P Reference
       Region 6zvd P 386-386 disorder
       Region 6zvd P 387-396 order
       Region 6zvd P 397-398 disorder
 Evidence X-RAY 6zve P Reference
       Region 6zve P 386-386 disorder
       Region 6zve P 387-396 order
       Region 6zve P 397-398 disorder
Seq 387-396 Hetero tetramer : IID00061Complex
 Evidence X-RAY 5exa C Reference
       Region 5exa C 387-395 order
       Region 5exa C 396-396 disorder
 Evidence X-RAY 5exa D Reference
       Region 5exa D 387-396 order
Seq 508-522 Hetero dimer : IID00459Complex
 Evidence X-RAY 2vwf B Reference
       Region 2vwf B 508-521 order
       Region 2vwf B 522-522 disorder
SeqProS predicted 207-211 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 6y3s P 207-211 order
SeqProS predicted 207-211,387-396 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00061Complex
       Region 5ewz D 207-212 order
       Region 5ewz C 387-395 order
SeqProS predicted 350-358 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00459Complex
       Region 2w0z B 350-358 order
SeqProS predicted 387-396 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 6y3r P 387-396 order
       Region 6zvc P 387-396 order
       Region 6zve P 387-396 order
       Region 6zvb P 387-396 order
       Region 6zvd P 387-396 order
SeqProS predicted 387-396 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00061Complex
       Region 5exa C 387-395 order
       Region 5exa D 387-396 order
SeqProS predicted 508-522 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00459Complex
       Region 2vwf B 508-521 order
Seqphosphorylation
    622-622 Phosphoserine
    385-385 Phosphothreonine
    391-391 Phosphothreonine
    405-405 Phosphoserine
    408-408 Phosphothreonine
    422-422 Phosphoserine
    425-425 Phosphoserine
    452-452 Phosphotyrosine
    480-480 Phosphoserine
    543-543 Phosphoserine
    368-368 Phosphoserine
    623-623 Phosphoserine
    643-643 Phosphotyrosine
    2-2 Phosphoserine
    264-264 Phosphoserine
    140-140 Phosphoserine
    141-141 Phosphoserine
    148-148 Phosphoserine
    149-149 Phosphoserine
    159-159 Phosphoserine
    164-164 Phosphoserine
    210-210 Phosphoserine
    218-218 Phosphoserine
    223-223 Phosphoserine
    133-133 Phosphoserine
    265-265 Phosphothreonine
    266-266 Phosphotyrosine
    278-278 Phosphothreonine
    281-281 Phosphoserine
    285-285 Phosphoserine
    287-287 Phosphothreonine
    293-293 Phosphotyrosine
    331-331 Phosphothreonine
 
Prediction
NeProc
Disorder 1-3,125-639,646-649,656-676
Order 4-124,640-645,650-655
ProS 125-129,167-174,190-226,263-271,290-297,374-412,420-439,450-455,472-488,513-521,527-557,582-588,597-601,610-621,646-649,656-676
AlphaFold
Disorder 1-5,19-25,39-40,74-82,119-192,198-198,200-452,454-454,456-614,616-640,667-676
Order 6-18,26-38,41-73,83-118,193-197,199-199,453-453,455-455,615-615,641-666
Pfam Hmmer
PF00169 7-117 6.2e-25
SEG 140-149 ,351-358
Function
Function in SwissProt
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Biological Process
Diagram with PDB data
GAB2/GRB2Grb2 SH3C (3)