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IID00523
 UniprotO14508
ProteinSuppressor of cytokine signaling 2
GeneSOCS2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
198
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 32-198 Hetero trimer : Q15369,Q15370
 Evidence X-RAY 2c9w A Reference
       Region 2c9w A 32-134 order
       Region 2c9w A 135-148 disorder
       Region 2c9w A 149-198 order
 Evidence X-RAY 5bo4 P Reference
       Region 5bo4 P 32-134 order
       Region 5bo4 P 135-148 disorder
       Region 5bo4 P 149-198 order
 Evidence X-RAY 5bo4 J Reference
       Region 5bo4 J 32-134 order
       Region 5bo4 J 135-148 disorder
       Region 5bo4 J 149-198 order
 Evidence X-RAY 5bo4 G Reference
       Region 5bo4 G 32-134 order
       Region 5bo4 G 135-148 disorder
       Region 5bo4 G 149-198 order
 Evidence X-RAY 5bo4 A Reference
       Region 5bo4 A 32-134 order
       Region 5bo4 A 135-148 disorder
       Region 5bo4 A 149-198 order
Seq 32-198 Hetero tetramer : IID00519Complex,IID50216Complex,IID50219Complex
 Evidence X-RAY 4jgh A Reference
       Region 4jgh A 32-135 order
       Region 4jgh A 136-145 disorder
       Region 4jgh A 146-198 order
Seq 32-198 Hetero trimer : Q15369
 Evidence X-RAY 5bo4 D Reference
       Region 5bo4 D 32-134 order
       Region 5bo4 D 135-148 disorder
       Region 5bo4 D 149-198 order
Seq 32-198 Hetero trimer : Q15369,Q15370
 Evidence X-RAY 5bo4 M Reference
       Region 5bo4 M 32-134 order
       Region 5bo4 M 135-148 disorder
       Region 5bo4 M 149-198 order
Seqphosphorylation
    52-52 Phosphoserine; by PKC
    30-30 Phosphoserine
 
Prediction
NeProc
Disorder 1-28
Order 29-198
ProS 1-6,18-28
AlphaFold
Disorder 1-28,108-115,136-149
Order 29-107,116-135,150-198
Pfam Hmmer
PF00017 48-129 8.5e-12
PF07525 160-195 4e-17
Function
Function in SwissProt
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.