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IID00528
 UniprotO43597
ProteinProtein sprouty homolog 2
GeneSPRY2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
315
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 36-60 Hetero dimer : IID00300Complex
 Evidence X-RAY 5hky B Reference
       Region 5hky B 36-38 disorder
       Region 5hky B 39-60 order
 Evidence X-RAY 5hkz B Reference
       Region 5hkz B 36-59 order
       Region 5hkz B 60-60 disorder
Seq 49-61 Hetero dimer : IID00300Complex
 Evidence X-RAY 3bum A Reference
       Region 3bum A 49-51 disorder
       Region 3bum A 52-60 order
       Region 3bum A 61-61 disorder
 Evidence X-RAY 3ob1 A Reference
       Region 3ob1 A 49-49 disorder
       Region 3ob1 A 50-59 order
       Region 3ob1 A 60-60 disorder
 Evidence X-RAY 5hl0 B Reference
       Region 5hl0 B 54-59 order
       Region 5hl0 B 60-60 disorder
SeqProS predicted 50-60 The unbound state of this region is deduced to be disordered based on the results of prediction tools (DICHOT, Mobi, d2p2 etc). Hetero dimer : IID00300Complex
       Region 5hky B 39-60 order
       Region 5hkz B 36-59 order
SeqProS predicted 50-60 The unbound state of this region is deduced to be disordered based on the results of prediction tools (DICHOT, Mobi, d2p2 etc). Hetero dimer : IID00300Complex
       Region 3ob1 A 50-59 order
       Region 3bum A 52-60 order
       Region 5hl0 B 54-59 order
 
Prediction
NeProc
Disorder 1-172,254-257,301-315
Order 173-253,258-300
ProS 11-23,28-33,38-62,129-135,147-159,254-257,301-304
AlphaFold
Disorder 1-40,49-173,231-237,245-247,302-315
Order 41-48,174-230,238-244,248-301
Pfam Hmmer
PF05210 36-294 2.3e-173
SEG 108-142 ,178-189
Function
Function in SwissProt
Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561).
Biological Process
Diagram with PDB data
SPRY2/CBLCrystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2