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IID00529
 UniprotO43791
ProteinSpeckle-type POZ protein
GeneSPOP
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
374
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 28-166 Hetero dimer : P60484
 Evidence X-RAY 4o1v A Reference
       Region 4o1v A 28-166 order
Seq 28-166 Hetero dimer :
 Evidence X-RAY 3hql A Reference
       Region 3hql A 28-59 order
       Region 3hql A 60-62 disorder
       Region 3hql A 63-164 order
       Region 3hql A 165-166 disorder
Seq 28-166 Hetero dimer :
 Evidence X-RAY 3ivq B Reference
       Region 3ivq B 28-60 order
       Region 3ivq B 61-63 disorder
       Region 3ivq B 64-166 order
Seq 28-166 Hetero trimer : O75367
 Evidence X-RAY 3hsv B Reference
       Region 3hsv B 28-59 order
       Region 3hsv B 60-64 disorder
       Region 3hsv B 65-164 order
       Region 3hsv B 165-166 disorder
 Evidence X-RAY 3hsv A Reference
       Region 3hsv A 28-59 order
       Region 3hsv A 60-64 disorder
       Region 3hsv A 65-165 order
       Region 3hsv A 166-166 disorder
Seq 28-166 Hetero dimer :
 Evidence X-RAY 3ivq A Reference
       Region 3ivq A 28-61 order
       Region 3ivq A 62-63 disorder
       Region 3ivq A 64-166 order
Seq 28-166 Hetero dimer :
 Evidence X-RAY 3hql B Reference
       Region 3hql B 28-59 order
       Region 3hql B 60-63 disorder
       Region 3hql B 64-93 order
       Region 3hql B 94-94 disorder
       Region 3hql B 95-164 order
       Region 3hql B 165-166 disorder
Seq 28-166 Hetero dimer : P19538
 Evidence X-RAY 3hqm B Reference
       Region 3hqm B 28-28 disorder
       Region 3hqm B 29-59 order
       Region 3hqm B 60-63 disorder
       Region 3hqm B 64-164 order
       Region 3hqm B 165-166 disorder
 Evidence X-RAY 3hqm A Reference
       Region 3hqm A 28-60 order
       Region 3hqm A 61-62 disorder
       Region 3hqm A 63-94 order
       Region 3hqm A 95-95 disorder
       Region 3hqm A 96-165 order
       Region 3hqm A 166-166 disorder
Seq 28-166 Hetero dimer :
 Evidence X-RAY 3ivv A Reference
       Region 3ivv A 28-165 order
       Region 3ivv A 166-166 disorder
Seq 28-166 Hetero dimer : O75367
 Evidence X-RAY 3ivb A Reference
       Region 3ivb A 28-95 order
       Region 3ivb A 96-96 disorder
       Region 3ivb A 97-165 order
       Region 3ivb A 166-166 disorder
 Evidence X-RAY 3hqh A Reference
       Region 3hqh A 28-60 order
       Region 3hqh A 61-62 disorder
       Region 3hqh A 63-94 order
       Region 3hqh A 95-96 disorder
       Region 3hqh A 97-165 order
       Region 3hqh A 166-166 disorder
Seq 28-173 Monomer :
 Evidence NMR 2cr2 A Reference
       Region 2cr2 A 28-173 order
       Region 2cr2 A 168-173 high_rmsd
Seq 28-329 Hetero tetramer :
 Evidence X-RAY 3hqi A Reference
       Region 3hqi A 28-59 order
       Region 3hqi A 60-61 disorder
       Region 3hqi A 62-77 order
       Region 3hqi A 78-79 disorder
       Region 3hqi A 80-95 order
       Region 3hqi A 96-96 disorder
       Region 3hqi A 97-231 order
       Region 3hqi A 232-236 disorder
       Region 3hqi A 237-329 order
 Evidence X-RAY 3hqi B Reference
       Region 3hqi B 28-60 order
       Region 3hqi B 61-63 disorder
       Region 3hqi B 64-77 order
       Region 3hqi B 78-79 disorder
       Region 3hqi B 80-95 order
       Region 3hqi B 96-96 disorder
       Region 3hqi B 97-168 order
       Region 3hqi B 169-176 disorder
       Region 3hqi B 177-231 order
       Region 3hqi B 232-237 disorder
       Region 3hqi B 238-329 order
Seq 28-329 Hetero tetramer :
 Evidence X-RAY 3hu6 A Reference
       Region 3hu6 A 28-59 order
       Region 3hu6 A 60-63 disorder
       Region 3hu6 A 64-77 order
       Region 3hu6 A 78-79 disorder
       Region 3hu6 A 80-95 order
       Region 3hu6 A 96-96 disorder
       Region 3hu6 A 97-167 order
       Region 3hu6 A 168-172 disorder
       Region 3hu6 A 173-173 order
       Region 3hu6 A 174-174 disorder
       Region 3hu6 A 175-231 order
       Region 3hu6 A 232-237 disorder
       Region 3hu6 A 238-329 order
 Evidence X-RAY 3hu6 B Reference
       Region 3hu6 B 28-60 order
       Region 3hu6 B 61-63 disorder
       Region 3hu6 B 64-95 order
       Region 3hu6 B 96-96 disorder
       Region 3hu6 B 97-108 order
       Region 3hu6 B 109-109 disorder
       Region 3hu6 B 110-167 order
       Region 3hu6 B 168-177 disorder
       Region 3hu6 B 178-231 order
       Region 3hu6 B 232-237 disorder
       Region 3hu6 B 238-329 order
Seq 169-374 Homo dimer :
 Evidence X-RAY 4j8z B Reference
       Region 4j8z B 169-177 disorder
       Region 4j8z B 178-354 order
       Region 4j8z B 355-374 disorder
 Evidence X-RAY 4j8z A Reference
       Region 4j8z A 169-177 disorder
       Region 4j8z A 178-356 order
       Region 4j8z A 357-374 disorder
 Evidence X-RAY 3htm D Reference
       Region 3htm D 172-176 disorder
       Region 3htm D 177-232 order
       Region 3htm D 233-233 disorder
       Region 3htm D 234-329 order
 Evidence X-RAY 3htm C Reference
       Region 3htm C 172-176 disorder
       Region 3htm C 177-232 order
       Region 3htm C 233-233 disorder
       Region 3htm C 234-329 order
 Evidence X-RAY 3htm B Reference
       Region 3htm B 172-176 disorder
       Region 3htm B 177-329 order
 Evidence X-RAY 3htm A Reference
       Region 3htm A 172-176 disorder
       Region 3htm A 177-329 order
Seq 177-319 Hetero dimer : Q13618
 Evidence X-RAY 4eoz C Reference
       Region 4eoz C 177-179 disorder
       Region 4eoz C 180-295 order
       Region 4eoz C 296-319 disorder
 Evidence X-RAY 4eoz A Reference
       Region 4eoz A 177-178 disorder
       Region 4eoz A 179-292 order
       Region 4eoz A 293-319 disorder
Seq 270-374 Homo dimer :
 Evidence X-RAY 4hs2 A Reference
       Region 4hs2 A 270-295 disorder
       Region 4hs2 A 296-359 order
       Region 4hs2 A 360-374 disorder
 
Prediction
NeProc
Disorder 1-19,365-374
Order 20-171,176-364
ProS 365-374
AlphaFold
Disorder 1-17,174-178,360-374
Order 18-173,179-359
Pfam Hmmer
PF00917 38-163 1.1e-21
PF00651 190-297 2.6e-38
SEG 266-282
Function
Function in SwissProt
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed:32109420).