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IID00530
 UniprotO75530
ProteinPolycomb protein EED
GeneEED
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
441
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 40-441 Hetero dimer : IID00058Complex
 Evidence X-RAY 3jpx A Reference
       Region 3jpx A 40-80 disorder
       Region 3jpx A 81-439 order
       Region 3jpx A 440-441 disorder
 Evidence X-RAY 3ij1 A Reference
       Region 3ij1 A 77-80 disorder
       Region 3ij1 A 81-439 order
       Region 3ij1 A 440-441 disorder
Seq 40-441 Hetero dimer :
 Evidence X-RAY 3jzh A This region binds to a peptide. Reference
       Region 3jzh A 40-80 disorder
       Region 3jzh A 81-439 order
       Region 3jzh A 440-441 disorder
Seq 40-441 Monomer :
 Evidence X-RAY 3jzn A Reference
       Region 3jzn A 76-81 disorder
       Region 3jzn A 82-439 order
       Region 3jzn A 440-441 disorder
 Evidence X-RAY 5u8f A Reference
       Region 5u8f A 77-81 disorder
       Region 5u8f A 82-439 order
       Region 5u8f A 440-441 disorder
 Evidence X-RAY 5u8a A Reference
       Region 5u8a A 77-81 disorder
       Region 5u8a A 82-439 order
       Region 5u8a A 440-441 disorder
 Evidence X-RAY 5u6d A Reference
       Region 5u6d A 77-81 disorder
       Region 5u6d A 82-439 order
       Region 5u6d A 440-441 disorder
 Evidence X-RAY 5u69 A Reference
       Region 5u69 A 77-81 disorder
       Region 5u69 A 82-439 order
       Region 5u69 A 440-441 disorder
 Evidence X-RAY 5u5k A Reference
       Region 5u5k A 76-78 disorder
       Region 5u5k A 79-395 order
       Region 5u5k A 396-399 disorder
       Region 5u5k A 400-440 order
       Region 5u5k A 441-441 disorder
 Evidence X-RAY 5u5h A Reference
       Region 5u5h A 76-78 disorder
       Region 5u5h A 79-393 order
       Region 5u5h A 394-400 disorder
       Region 5u5h A 401-440 order
       Region 5u5h A 441-441 disorder
 Evidence X-RAY 5ttw C Reference
       Region 5ttw C 76-77 disorder
       Region 5ttw C 78-336 order
       Region 5ttw C 337-337 disorder
       Region 5ttw C 338-393 order
       Region 5ttw C 394-397 disorder
       Region 5ttw C 398-440 order
       Region 5ttw C 441-441 disorder
 Evidence X-RAY 5ttw A Reference
       Region 5ttw A 76-78 disorder
       Region 5ttw A 79-336 order
       Region 5ttw A 337-337 disorder
       Region 5ttw A 338-393 order
       Region 5ttw A 394-394 disorder
       Region 5ttw A 395-440 order
       Region 5ttw A 441-441 disorder
 Evidence X-RAY 5k0m A Reference
       Region 5k0m A 77-81 disorder
       Region 5k0m A 82-440 order
       Region 5k0m A 441-441 disorder
 Evidence X-RAY 3jzg A This region binds to a peptide. Reference
       Region 3jzg A 40-80 disorder
       Region 3jzg A 81-439 order
       Region 3jzg A 440-441 disorder
 Evidence X-RAY 3ijc A Reference
       Region 3ijc A 77-79 disorder
       Region 3ijc A 80-106 order
       Region 3ijc A 107-110 disorder
       Region 3ijc A 111-440 order
       Region 3ijc A 441-441 disorder
 Evidence X-RAY 5h13 A Reference
       Region 5h13 A 76-104 order
       Region 5h13 A 105-110 disorder
       Region 5h13 A 111-280 order
       Region 5h13 A 281-288 disorder
       Region 5h13 A 289-440 order
       Region 5h13 A 441-441 disorder
Seq 75-441 Hetero dimer :
 Evidence X-RAY 5wp3 A Reference
       Region 5wp3 A 75-76 disorder
       Region 5wp3 A 77-283 order
       Region 5wp3 A 284-288 disorder
       Region 5wp3 A 289-441 order
Seq 76-441 Hetero dimer :
 Evidence X-RAY 3k27 A This region binds to a peptide. Reference
       Region 3k27 A 76-79 disorder
       Region 3k27 A 80-439 order
       Region 3k27 A 440-441 disorder
Seq 76-441 Hetero dimer :
 Evidence X-RAY 3k26 A This region binds to a peptide. Reference
       Region 3k26 A 76-79 disorder
       Region 3k26 A 80-439 order
       Region 3k26 A 440-441 disorder
Seq 76-441 Hetero dimer : IID00727Complex
 Evidence X-RAY 5wuk A Reference
       Region 5wuk A 76-441 order
 Evidence X-RAY 5u62 B Reference
       Region 5u62 B 76-79 disorder
       Region 5u62 B 80-393 order
       Region 5u62 B 394-400 disorder
       Region 5u62 B 401-440 order
       Region 5u62 B 441-441 disorder
 Evidence X-RAY 5u62 A Reference
       Region 5u62 A 76-78 disorder
       Region 5u62 A 79-280 order
       Region 5u62 A 281-286 disorder
       Region 5u62 A 287-393 order
       Region 5u62 A 394-400 disorder
       Region 5u62 A 401-440 order
       Region 5u62 A 441-441 disorder
 Evidence X-RAY 5u5t B Reference
       Region 5u5t B 76-79 disorder
       Region 5u5t B 80-281 order
       Region 5u5t B 282-287 disorder
       Region 5u5t B 288-393 order
       Region 5u5t B 394-400 disorder
       Region 5u5t B 401-440 order
       Region 5u5t B 441-441 disorder
 Evidence X-RAY 5u5t A Reference
       Region 5u5t A 76-78 disorder
       Region 5u5t A 79-280 order
       Region 5u5t A 281-288 disorder
       Region 5u5t A 289-394 order
       Region 5u5t A 395-400 disorder
       Region 5u5t A 401-440 order
       Region 5u5t A 441-441 disorder
 Evidence X-RAY 5h25 B Reference
       Region 5h25 B 76-76 disorder
       Region 5h25 B 77-280 order
       Region 5h25 B 281-287 disorder
       Region 5h25 B 288-440 order
       Region 5h25 B 441-441 disorder
 Evidence X-RAY 5h25 A Reference
       Region 5h25 A 76-76 disorder
       Region 5h25 A 77-440 order
       Region 5h25 A 441-441 disorder
 Evidence X-RAY 5h24 B Reference
       Region 5h24 B 76-76 disorder
       Region 5h24 B 77-281 order
       Region 5h24 B 282-286 disorder
       Region 5h24 B 287-440 order
       Region 5h24 B 441-441 disorder
 Evidence X-RAY 5h24 A Reference
       Region 5h24 A 76-76 disorder
       Region 5h24 A 77-440 order
       Region 5h24 A 441-441 disorder
 Evidence X-RAY 5h19 A Reference
       Region 5h19 A 76-77 disorder
       Region 5h19 A 78-282 order
       Region 5h19 A 283-287 disorder
       Region 5h19 A 288-394 order
       Region 5h19 A 395-397 disorder
       Region 5h19 A 398-440 order
       Region 5h19 A 441-441 disorder
 Evidence X-RAY 5h17 A Reference
       Region 5h17 A 76-76 disorder
       Region 5h17 A 77-280 order
       Region 5h17 A 281-287 disorder
       Region 5h17 A 288-440 order
       Region 5h17 A 441-441 disorder
 Evidence X-RAY 5h15 B Reference
       Region 5h15 B 76-76 disorder
       Region 5h15 B 77-440 order
       Region 5h15 B 441-441 disorder
 Evidence X-RAY 5h15 A Reference
       Region 5h15 A 76-77 disorder
       Region 5h15 A 78-280 order
       Region 5h15 A 281-287 disorder
       Region 5h15 A 288-440 order
       Region 5h15 A 441-441 disorder
 Evidence X-RAY 5h14 B Reference
       Region 5h14 B 76-76 disorder
       Region 5h14 B 77-280 order
       Region 5h14 B 281-287 disorder
       Region 5h14 B 288-440 order
       Region 5h14 B 441-441 disorder
 Evidence X-RAY 5h14 A Reference
       Region 5h14 A 76-440 order
       Region 5h14 A 441-441 disorder
 Evidence X-RAY 5gsa B Reference
       Region 5gsa B 76-77 disorder
       Region 5gsa B 78-440 order
       Region 5gsa B 441-441 disorder
 Evidence X-RAY 5gsa A Reference
       Region 5gsa A 76-77 disorder
       Region 5gsa A 78-282 order
       Region 5gsa A 283-286 disorder
       Region 5gsa A 287-440 order
       Region 5gsa A 441-441 disorder
Seq 77-441 Hetero tetramer : IID00725Complex,IID00727Complex,Q92833
 Evidence X-RAY 5ls6 H Reference
       Region 5ls6 H 77-441 order
Seq 77-441 Hetero pentamer : IID00725Complex,IID00727Complex,Q92833
 Evidence X-RAY 5hyn R Reference
       Region 5hyn R 77-441 order
 Evidence X-RAY 5hyn L Reference
       Region 5hyn L 77-441 order
 Evidence X-RAY 5hyn G Reference
       Region 5hyn G 77-441 order
 Evidence X-RAY 5hyn B Reference
       Region 5hyn B 77-441 order
Seq 77-441 Hetero dimer :
 Evidence X-RAY 3iiy A This region binds to a peptide. Reference
       Region 3iiy A 77-440 order
       Region 3iiy A 441-441 disorder
Seq 77-441 Hetero tetramer : IID00725Complex,IID00727Complex,Q92833
 Evidence X-RAY 5ls6 K Reference
       Region 5ls6 K 77-441 order
Seq 77-441 Hetero dimer :
 Evidence X-RAY 4x3e A Reference
       Region 4x3e A 77-80 disorder
       Region 4x3e A 81-439 order
       Region 4x3e A 440-441 disorder
Seq 77-441 Hetero dimer :
 Evidence X-RAY 3ij0 A This region binds to a peptide. Reference
       Region 3ij0 A 77-80 disorder
       Region 3ij0 A 81-439 order
       Region 3ij0 A 440-441 disorder
Seq 77-441 Hetero tetramer : IID00725Complex,IID00727Complex,Q92833
 Evidence X-RAY 5ls6 E Reference
       Region 5ls6 E 77-441 order
Seq 77-441 Hetero dimer :
 Evidence X-RAY 3iiw A This region binds to a peptide. Reference
       Region 3iiw A 77-80 disorder
       Region 3iiw A 81-439 order
       Region 3iiw A 440-441 disorder
Seq 77-441 Hetero tetramer : IID00725Complex,IID00727Complex,Q92833
 Evidence X-RAY 5ls6 B Reference
       Region 5ls6 B 77-441 order
Seq 81-441 Hetero trimer : G1KPH4,IID00725Complex,IID00727Complex
 Evidence X-RAY 5ij8 F Reference
       Region 5ij8 F 81-81 disorder
       Region 5ij8 F 82-440 order
       Region 5ij8 F 441-441 disorder
Seq 81-441 Hetero trimer : G1KPH4,IID00725Complex,IID00727Complex
 Evidence X-RAY 5ij8 E Reference
       Region 5ij8 E 81-81 disorder
       Region 5ij8 E 82-439 order
       Region 5ij8 E 440-441 disorder
Seq 81-441 Hetero trimer : G1KPH4,IID00725Complex
 Evidence X-RAY 4w2r F Reference
       Region 4w2r F 81-81 disorder
       Region 4w2r F 82-440 order
       Region 4w2r F 441-441 disorder
Seq 81-441 Hetero trimer : G1KPH4,IID00725Complex
 Evidence X-RAY 4w2r E Reference
       Region 4w2r E 81-81 disorder
       Region 4w2r E 82-439 order
       Region 4w2r E 440-441 disorder
Seq 81-441 Hetero trimer : G1KPH4,IID00725Complex
 Evidence X-RAY 6b3w E Reference
       Region 6b3w E 81-81 disorder
       Region 6b3w E 82-439 order
       Region 6b3w E 440-441 disorder
Seq 81-441 Hetero trimer : G1KPH4,IID00725Complex,IID00727Complex
 Evidence X-RAY 5ij7 E Reference
       Region 5ij7 E 81-394 order
       Region 5ij7 E 395-399 disorder
       Region 5ij7 E 400-440 order
       Region 5ij7 E 441-441 disorder
Seq 81-441 Hetero trimer : G1KPH4,IID00725Complex,IID00727Complex
 Evidence X-RAY 5ij7 F Reference
       Region 5ij7 F 81-440 order
       Region 5ij7 F 441-441 disorder
Seq 81-441 Hetero trimer : G1KPH4,IID00725Complex
 Evidence X-RAY 6b3w F Reference
       Region 6b3w F 81-81 disorder
       Region 6b3w F 82-440 order
       Region 6b3w F 441-441 disorder
Seqphosphorylation
    34-34 Phosphoserine
    2-2 Phosphoserine
    55-55 Phosphothreonine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-45,50-71
Order 46-49,72-441
ProS 5-45,50-71
AlphaFold
Disorder 1-77
Order 78-441
Pfam Hmmer
PF00400 180-219 6.4e-08
SEG 66-84
Function
Function in SwissProt
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Biological Process
See also
Diagram with PDB data
SUZ12/RBBP4/PHF19/JARID2Crystal Structure of a SUZ12-RBBP4-PHF19-JARID2 Heterotetrameric Complex
EZH2/EED/SUZ12/H3C1/JARID2Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide