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IID00531
 UniprotO75581
ProteinLow-density lipoprotein receptor-related protein 6
GeneLRP6
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1613
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 20-326 Hetero dimer : IID00584Complex
 Evidence X-RAY 3sov A Reference
       Region 3sov A 20-325 order
       Region 3sov A 326-326 disorder
Seq 20-326 Hetero dimer : IID00532Complex
 Evidence X-RAY 3soq A Reference
       Region 3soq A 20-324 order
       Region 3soq A 325-326 disorder
Seq 20-335 Hetero trimer :
 Evidence X-RAY 3sob B Reference
       Region 3sob B 20-324 order
       Region 3sob B 325-335 disorder
Seq 20-635 Monomer :
 Evidence X-RAY 3s94 B Reference
       Region 3s94 B 20-22 disorder
       Region 3s94 B 23-35 order
       Region 3s94 B 36-45 disorder
       Region 3s94 B 46-81 order
       Region 3s94 B 82-85 disorder
       Region 3s94 B 86-220 order
       Region 3s94 B 221-226 disorder
       Region 3s94 B 227-264 order
       Region 3s94 B 265-268 disorder
       Region 3s94 B 269-629 order
       Region 3s94 B 630-630 disorder
 Evidence X-RAY 3s94 A Reference
       Region 3s94 A 20-20 disorder
       Region 3s94 A 21-37 order
       Region 3s94 A 38-46 disorder
       Region 3s94 A 47-80 order
       Region 3s94 A 81-85 disorder
       Region 3s94 A 86-217 order
       Region 3s94 A 218-226 disorder
       Region 3s94 A 227-630 order
 Evidence X-RAY 4dg6 A Reference
       Region 4dg6 A 20-635 order
Seq 629-1244 Monomer :
 Evidence X-RAY 3s8z A Reference
       Region 3s8z A 629-1004 order
       Region 3s8z A 1005-1013 disorder
       Region 3s8z A 1014-1243 order
 Evidence X-RAY 4a0p A Reference
       Region 4a0p A 629-629 disorder
       Region 4a0p A 630-1004 order
       Region 4a0p A 1005-1012 disorder
       Region 4a0p A 1013-1244 order
Seq 629-1246 Hetero trimer : IID00532Complex
 Evidence X-RAY 3s8v B Reference
       Region 3s8v B 629-630 disorder
       Region 3s8v B 631-1004 order
       Region 3s8v B 1005-1013 disorder
       Region 3s8v B 1014-1243 order
 Evidence X-RAY 3s8v A Reference
       Region 3s8v A 629-908 order
       Region 3s8v A 909-910 disorder
       Region 3s8v A 911-952 order
       Region 3s8v A 953-954 disorder
       Region 3s8v A 955-1005 order
       Region 3s8v A 1006-1013 disorder
       Region 3s8v A 1014-1172 order
       Region 3s8v A 1173-1175 disorder
       Region 3s8v A 1176-1243 order
 Evidence X-RAY 3s2k B Reference
       Region 3s2k B 630-1005 order
       Region 3s2k B 1006-1012 disorder
       Region 3s2k B 1013-1246 order
 Evidence X-RAY 3s2k A Reference
       Region 3s2k A 630-1005 order
       Region 3s2k A 1006-1012 disorder
       Region 3s2k A 1013-1246 order
Seq 630-1246 Hetero trimer : IID00532Complex
 Evidence X-RAY 5fww A Reference
       Region 5fww A 630-1005 order
       Region 5fww A 1006-1012 disorder
       Region 5fww A 1013-1246 order
Seqdisorder 1565-1575
 Evidence X-RAY 5air A This region is the chimera protein. Reference
       Region 5air A 1565-1575 disorder
Seqdisorder 1565-1575
 Evidence X-RAY 5air B This region is the chimera protein. Reference
       Region 5air B 1565-1575 disorder
Seq 1568-1575 Hetero trimer : IID00052Complex
 Evidence X-RAY 4nm5 C Reference
       Region 4nm5 C 1568-1568 disorder
       Region 4nm5 C 1569-1574 order
       Region 4nm5 C 1575-1575 disorder
Seq 1603-1610 Hetero trimer : IID00052Complex
 Evidence X-RAY 4nm7 C Reference
       Region 4nm7 C 1603-1603 disorder
       Region 4nm7 C 1604-1609 order
       Region 4nm7 C 1610-1610 disorder
Seqphosphorylation
    1493-1493 Phosphothreonine; by CK1
    1490-1490 Phosphoserine; by CDK14
    1479-1479 Phosphothreonine
    1430-1430 Phosphoserine; by CK1
    1420-1420 Phosphoserine; by CK1
 
Prediction
NeProc
Disorder 1427-1480,1577-1613
Order 1-1426,1481-1576
ProS 1427-1480,1577-1613
AlphaFold
Disorder 1-20,38-41,83-84,531-531,617-617,629-631,649-652,1005-1012,1246-1251,1257-1262,1284-1291,1321-1329,1359-1613
Order 21-37,42-82,85-530,532-616,618-628,632-648,653-1004,1013-1245,1252-1256,1263-1283,1292-1320,1330-1358
Pfam Hmmer
PF00058 63-105 2.1e-05
PF00058 107-148 3.2e-12
PF00058 150-192 2.4e-15
PF00058 194-235 4.1e-08
PF00008 286-323 2.7e-07
PF00058 372-413 1.2e-08
PF00058 415-456 6.2e-13
PF00058 458-500 1.4e-13
PF00008 592-627 3.2e-06
PF00058 674-715 1.7e-08
PF00058 717-758 1e-09
PF00058 760-801 1.7e-08
PF00058 843-884 6.9e-06
PF00008 893-929 0.00085
PF00058 1069-1112 1e-06
PF00058 1114-1155 1.1e-08
PF00008 1207-1243 2.8e-06
PF00057 1247-1285 1.8e-14
PF00057 1286-1322 4.8e-14
PF00057 1324-1360 2.1e-11
SEG 330-341 ,1373-1390 ,1429-1438 ,1444-1457 ,1469-1475 ,1508-1524 ,1566-1573 ,1596-1608
Function
Function in SwissProt
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Biological Process
See also
Diagram with PDB data
AXIN1/GSK3BCrystal structure of GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide
DKK1/ LRP6The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide
DKK1/LRP6/KREMEN1Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4)
SOST/LRP6The structure of a beta propeller domain in complex with peptide S