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IID00539
 UniprotP10828
ProteinThyroid hormone receptor beta
GeneTHRB
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
461
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 104-204 Hetero dimer :
 Evidence X-RAY 2nll B Reference
       Region 2nll B 104-204 order
Seq 202-461 Hetero tetramer :
 Evidence X-RAY 1bsx B Reference
       Region 1bsx B 202-210 disorder
       Region 1bsx B 211-254 order
       Region 1bsx B 255-262 disorder
       Region 1bsx B 263-461 order
 Evidence X-RAY 1bsx A Reference
       Region 1bsx A 202-210 disorder
       Region 1bsx A 211-254 order
       Region 1bsx A 255-262 disorder
       Region 1bsx A 263-461 order
Seq 202-461 Monomer :
 Evidence X-RAY 1y0x X Reference
       Region 1y0x X 202-251 order
       Region 1y0x X 252-263 disorder
       Region 1y0x X 264-460 order
       Region 1y0x X 461-461 disorder
 Evidence X-RAY 1xzx X Reference
       Region 1xzx X 202-251 order
       Region 1xzx X 252-263 disorder
       Region 1xzx X 264-460 order
       Region 1xzx X 461-461 disorder
 Evidence X-RAY 1r6g A Reference
       Region 1r6g A 203-234 order
       Region 1r6g A 235-242 disorder
       Region 1r6g A 243-252 order
       Region 1r6g A 253-263 disorder
       Region 1r6g A 264-460 order
       Region 1r6g A 461-461 disorder
 Evidence X-RAY 1q4x A Reference
       Region 1q4x A 209-247 order
       Region 1q4x A 248-261 disorder
       Region 1q4x A 262-461 order
 Evidence X-RAY 1nuo A Reference
       Region 1nuo A 202-234 order
       Region 1nuo A 235-235 disorder
       Region 1nuo A 236-252 order
       Region 1nuo A 253-264 disorder
       Region 1nuo A 265-460 order
       Region 1nuo A 461-461 disorder
 Evidence X-RAY 1nq2 A Reference
       Region 1nq2 A 202-253 order
       Region 1nq2 A 254-261 disorder
       Region 1nq2 A 262-460 order
       Region 1nq2 A 461-461 disorder
 Evidence X-RAY 1nq1 A Reference
       Region 1nq1 A 202-252 order
       Region 1nq1 A 253-262 disorder
       Region 1nq1 A 263-461 order
 Evidence X-RAY 1nq0 A Reference
       Region 1nq0 A 202-252 order
       Region 1nq0 A 253-262 disorder
       Region 1nq0 A 263-461 order
 Evidence X-RAY 1nax A Reference
       Region 1nax A 209-210 disorder
       Region 1nax A 211-460 order
 Evidence X-RAY 3jzc A Reference
       Region 3jzc A 202-252 order
       Region 3jzc A 253-263 disorder
       Region 3jzc A 264-460 order
       Region 3jzc A 461-461 disorder
 Evidence X-RAY 2j4a A Reference
       Region 2j4a A 209-210 disorder
       Region 2j4a A 211-460 order
       Region 2j4a A 461-461 disorder
 Evidence X-RAY 3imy A Reference
       Region 3imy A 202-252 order
       Region 3imy A 253-262 disorder
       Region 3imy A 263-461 order
 Evidence X-RAY 3gws X Reference
       Region 3gws X 202-251 order
       Region 3gws X 252-263 disorder
       Region 3gws X 264-412 order
       Region 3gws X 413-413 disorder
       Region 3gws X 414-460 order
Seq 204-461 Homo dimer :
 Evidence X-RAY 2pin B Reference
       Region 2pin B 209-210 disorder
       Region 2pin B 211-460 order
       Region 2pin B 461-461 disorder
 Evidence X-RAY 2pin A Reference
       Region 2pin A 209-209 disorder
       Region 2pin A 210-254 order
       Region 2pin A 255-260 disorder
       Region 2pin A 261-460 order
       Region 2pin A 461-461 disorder
 Evidence X-RAY 1n46 B Reference
       Region 1n46 B 204-210 disorder
       Region 1n46 B 211-235 order
       Region 1n46 B 236-238 disorder
       Region 1n46 B 239-253 order
       Region 1n46 B 254-262 disorder
       Region 1n46 B 263-461 order
 Evidence X-RAY 1n46 A Reference
       Region 1n46 A 204-210 disorder
       Region 1n46 A 211-235 order
       Region 1n46 A 236-238 disorder
       Region 1n46 A 239-461 order
 Evidence X-RAY 3d57 B Reference
       Region 3d57 B 209-210 disorder
       Region 3d57 B 211-255 order
       Region 3d57 B 256-257 disorder
       Region 3d57 B 258-460 order
 Evidence X-RAY 3d57 A Reference
       Region 3d57 A 209-209 disorder
       Region 3d57 A 210-254 order
       Region 3d57 A 255-260 disorder
       Region 3d57 A 261-460 order
Seq 210-461 Hetero trimer : IID00031Complex,IID00082Complex
 Evidence X-RAY 4zo1 X Reference
       Region 4zo1 X 210-253 order
       Region 4zo1 X 254-263 disorder
       Region 4zo1 X 264-461 order
 
Prediction
NeProc
Disorder 1-101,208-218,250-265
Order 102-207,219-245,266-461
ProS 8-21
AlphaFold
Disorder 1-95,207-209,254-262
Order 96-206,210-253,263-461
Pfam Hmmer
PF00105 105-182 4.5e-50
PF00104 277-458 5.6e-42
SEG 188-203
Function
Function in SwissProt
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.