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IID00541
 UniprotP15923
ProteinTranscription factor E2-alpha
GeneTCF3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
654
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-37 Hetero dimer : IID00070Complex
 Evidence NMR 2mh0 A Reference
       Region 2mh0 A 1-37 order
       Region 2mh0 A 1-5 high_rmsd
       Region 2mh0 A 33-37 high_rmsd
Seq 546-616 Hetero tetramer : IID00268Complex,IID00543Complex
 Evidence X-RAY 2ypa B Reference
       Region 2ypa B 546-614 order
       Region 2ypa B 615-616 disorder
Seq 546-616 Hetero dimer : IID00543Complex
 Evidence X-RAY 2ypb B Reference
       Region 2ypb B 546-612 order
       Region 2ypb B 613-616 disorder
Seq 563-613 Homo dimer : IID50243Complex
 Evidence X-RAY 3u5v A Reference
       Region 3u5v A 563-613 order
Seqphosphorylation
    531-531 Phosphothreonine
    139-139 Phosphoserine
    529-529 Phosphoserine
    379-379 Phosphoserine
    359-359 Phosphoserine
    355-355 Phosphothreonine
    134-134 Phosphoserine
 
Prediction
NeProc
Disorder 1-553,620-654
Order 554-619
ProS 7-38,72-84,92-116,133-139,173-201,207-218,225-228,337-342,380-385,392-407,415-421,477-482,498-502,520-531,537-553,646-654
AlphaFold
Disorder 1-14,29-332,335-335,337-387,389-390,409-538,612-612,614-649,651-654
Order 15-28,333-334,336-336,388-388,391-408,539-611,613-613,650-650
Pfam Hmmer
PF00010 550-603 1.6e-12
SEG 55-68 ,80-94 ,147-160 ,235-268 ,285-299 ,341-354 ,496-506 ,530-541
Function
Function in SwissProt
Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with TCF15, required for the mesenchymal to epithelial transition. Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity).