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IID00545
 UniprotP21675
ProteinTranscription initiation factor TFIID subunit 1
GeneTAF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1872
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 579-1215 Hetero dimer : Q15545
 Evidence X-RAY 4rgw A Reference
       Region 4rgw A 579-587 disorder
       Region 4rgw A 588-908 order
       Region 4rgw A 909-921 disorder
       Region 4rgw A 922-971 order
       Region 4rgw A 972-1053 disorder
       Region 4rgw A 1054-1088 order
       Region 4rgw A 1089-1215 disorder
Seq 1342-1629 Hetero trimer : IID00182Complex
 Evidence X-RAY 3aad A Reference
       Region 3aad A 1342-1352 disorder
       Region 3aad A 1353-1366 order
       Region 3aad A 1367-1378 disorder
       Region 3aad A 1379-1628 order
       Region 3aad A 1629-1629 disorder
Seq 1359-1638 Monomer :
 Evidence X-RAY 3uv5 A Reference
       Region 3uv5 A 1373-1376 disorder
       Region 3uv5 A 1377-1631 order
       Region 3uv5 A 1632-1635 disorder
 Evidence X-RAY 6fic T Reference
       Region 6fic T 1359-1376 disorder
       Region 6fic T 1377-1621 order
       Region 6fic T 1622-1638 disorder
 Evidence X-RAY 1eqf A Reference
       Region 1eqf A 1359-1625 order
       Region 1eqf A 1626-1638 disorder
Seq 1497-1638 Hetero trimer : IID00058Complex
 Evidence X-RAY 4yyn B Reference
       Region 4yyn B 1497-1501 disorder
       Region 4yyn B 1502-1629 order
       Region 4yyn B 1630-1638 disorder
 Evidence X-RAY 4yyn A Reference
       Region 4yyn A 1497-1500 disorder
       Region 4yyn A 1501-1630 order
       Region 4yyn A 1631-1638 disorder
 Evidence X-RAY 4yym B Reference
       Region 4yym B 1497-1499 disorder
       Region 4yym B 1500-1632 order
       Region 4yym B 1633-1638 disorder
 Evidence X-RAY 4yym A Reference
       Region 4yym A 1497-1499 disorder
       Region 4yym A 1500-1631 order
       Region 4yym A 1632-1638 disorder
Seq 1497-1638 Monomer :
 Evidence X-RAY 5mg2 A Reference
       Region 5mg2 A 1501-1635 order
 Evidence X-RAY 3uv4 B Reference
       Region 3uv4 B 1501-1624 order
       Region 3uv4 B 1625-1635 disorder
 Evidence X-RAY 3uv4 A Reference
       Region 3uv4 A 1501-1623 order
       Region 3uv4 A 1624-1635 disorder
 Evidence X-RAY 5i29 A Reference
       Region 5i29 A 1497-1499 disorder
       Region 5i29 A 1500-1638 order
 Evidence X-RAY 5i1q A Reference
       Region 5i1q A 1497-1500 disorder
       Region 5i1q A 1501-1635 order
       Region 5i1q A 1636-1638 disorder
Seqphosphorylation
    1721-1721 Phosphoserine
    1723-1723 Phosphoserine
    1721-1721 Phosphoserine
    1718-1718 Phosphoserine
    1847-1847 Phosphoserine
    1820-1820 Phosphoserine
    1802-1802 Phosphoserine
    1799-1799 Phosphoserine
    1693-1693 Phosphoserine
    1690-1690 Phosphoserine
    328-328 Phosphoserine; by autocatalysis
    137-137 Phosphoserine; by autocatalysis
Seqacetylation
    565-565 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-33,83-242,281-311,316-328,335-356,390-417,422-430,443-470,542-607,641-682,935-942,990-1007,1059-1074,1084-1093,1098-1125,1154-1183,1266-1398,1642-1893
Order 34-82,243-269,274-280,312-315,329-334,357-389,418-421,431-442,471-541,608-640,683-934,943-989,1008-1053,1075-1083,1094-1097,1126-1153,1184-1265,1399-1641
ProS 1-16,96-119,128-148,238-242,281-289,316-328,335-340,345-356,413-417,422-430,454-470,542-548,580-597,604-607,641-675,935-942,1059-1074,1084-1093,1098-1108,1119-1125,1276-1313,1331-1360,1365-1398,1648-1672,1704-1713,1718-1736,1759-1764,1776-1784,1840-1845,1862-1872,1880-1886
AlphaFold
Disorder 1-46,48-48,50-58,62-63,65-300,302-341,344-345,359-364,370-482,495-587,856-858,909-921,973-996,1038-1038,1040-1053,1084-1103,1105-1118,1128-1129,1132-1162,1205-1205,1208-1218,1220-1220,1239-1262,1282-1322,1324-1324,1338-1379,1500-1500,1629-1629,1631-1872
Order 47-47,49-49,59-61,64-64,301-301,342-343,346-358,365-369,483-494,588-855,859-908,922-972,997-1037,1039-1039,1054-1083,1104-1104,1119-1127,1130-1131,1163-1204,1206-1207,1219-1219,1221-1238,1263-1281,1323-1323,1325-1337,1380-1499,1501-1628,1630-1630
Pfam Hmmer
PF00439 1406-1493 5.9e-27
PF00439 1528-1616 2.5e-38
SEG 11-20 ,66-75 ,138-153 ,157-165 ,185-212 ,280-288 ,291-309 ,543-559 ,1105-1117 ,1135-1155 ,1242-1257 ,1260-1282 ,1318-1325 ,1362-1379 ,1495-1514 ,1644-1655 ,1657-1668 ,1709-1723 ,1740-1756 ,1767-1777 ,1848-1857 ,1871-1879
Function
Function in SwissProt
Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).
Biological Process
See also
Diagram with PDB data
TP53/GTF2H1Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain