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IID00548
 UniprotP29083
ProteinGeneral transcription factor IIE subunit 1
GeneGTF2E1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
439
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-217 Hetero dimer : P29084
 Evidence X-RAY 5gpy A Reference
       Region 5gpy A 1-9 disorder
       Region 5gpy A 10-164 order
       Region 5gpy A 165-174 disorder
       Region 5gpy A 175-196 order
       Region 5gpy A 197-217 disorder
Seq 113-174 Monomer :
 Evidence NMR 1vd4 A Reference
       Region 1vd4 A 113-125 disorder
       Region 1vd4 A 113-123 high_rmsd
       Region 1vd4 A 126-164 order
       Region 1vd4 A 165-174 disorder
       Region 1vd4 A 169-174 high_rmsd
Seq 336-439 Monomer :
 Evidence NMR 2rnq A Reference
       Region 2rnq A 378-393 disorder
       Region 2rnq A 378-391 high_rmsd
       Region 2rnq A 394-434 order
       Region 2rnq A 435-439 disorder
       Region 2rnq A 435-439 high_rmsd
 Evidence NMR 2jtx A Reference
       Region 2jtx A 336-393 disorder
       Region 2jtx A 380-390 high_rmsd
       Region 2jtx A 394-432 order
       Region 2jtx A 433-439 disorder
       Region 2jtx A 436-439 high_rmsd
Seq 378-439 Hetero dimer : IID00549Complex
 Evidence NMR 2rnr A Reference
       Region 2rnr A 378-439 order
       Region 2rnr A 378-379 high_rmsd
       Region 2rnr A 439-439 high_rmsd
SeqProS verified 435-439 Hetero dimer : IID00549Complex
       Region 2rnr A 378-439 order
       Region 2rnq A 435-439 disorder
Seqphosphorylation
    268-268 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    67-67 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-8,219-390
Order 9-218,391-439
ProS 5-8,237-241,248-253,275-287,294-301,319-332
AlphaFold
Disorder 1-10,81-82,123-125,165-172,196-276,285-316,328-392,439-439
Order 11-80,83-122,126-164,173-195,277-284,317-327,393-438
Pfam Hmmer
PF02002 20-193 3.6e-97
SEG 220-235 ,333-344 ,352-365 ,378-393
Function
Function in SwissProt
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.