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IID00555
 UniprotP52655
ProteinTranscription initiation factor IIA subunit 1
GeneGTF2A1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
376
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-58,303-376 Hetero tetramer : IID00556Complex
 Evidence X-RAY 1nvp C Reference
       Region 1nvp C 303-329 disorder
       Region 1nvp C 330-376 order
 Evidence X-RAY 1nvp B Reference
       Region 1nvp B 2-8 disorder
       Region 1nvp B 9-51 order
       Region 1nvp B 52-58 disorder
Seq 2-58,328-376 Monomer : IID00556Complex
 Evidence X-RAY 5m4s A Reference
       Region 5m4s A 2-58 order
       Region 5m4s A 328-376 order
Seqphosphorylation
    321-321 Phosphoserine; by TAF1
    316-316 Phosphoserine; by TAF1
    281-281 Phosphoserine; by TAF1
    280-280 Phosphoserine; by TAF1
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-6,72-331
Order 7-70,332-376
ProS 141-165,184-191,205-208,215-234,259-293,310-317
AlphaFold
Disorder 1-8,57-312,314-317,319-330
Order 9-56,313-313,318-318,331-376
Pfam Hmmer
PF03153 12-376 1e-196
SEG 64-105 ,129-145 ,177-191 ,233-268 ,274-307
Function
Function in SwissProt
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.