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IID00557
 UniprotP55075
ProteinFibroblast growth factor 8
GeneFGF8
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
233
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 52-204 Hetero dimer : IID00546Complex
 Evidence X-RAY 2fdb N Reference
       Region 2fdb N 52-197 order
       Region 2fdb N 198-204 disorder
 Evidence X-RAY 2fdb M Reference
       Region 2fdb M 52-198 order
       Region 2fdb M 199-204 disorder
 
Prediction
NeProc
Disorder 1-61,183-233
Order 62-182
ProS 7-42,52-61,183-201,207-216
AlphaFold
Disorder 1-14,19-49,200-233
Order 15-18,50-199
Pfam Hmmer
PF00167 70-196 4.3e-65
SEG 8-20
Function
Function in SwissProt
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111).