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IID00558
 UniprotP63146
ProteinUbiquitin-conjugating enzyme E2 B
GeneUBE2B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
152
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-152 Monomer :
 Evidence X-RAY 2yb6 A Reference
       Region 2yb6 A 1-1 disorder
       Region 2yb6 A 2-150 order
       Region 2yb6 A 151-152 disorder
 Evidence NMR 1jas A Reference
       Region 1jas A 1-152 order
 Evidence NMR 2y4w A Reference
       Region 2y4w A 1-152 order
       Region 2y4w A 151-152 high_rmsd
Seq 1-152 Hetero dimer : IID00588Complex
 Evidence X-RAY 2ybf A Reference
       Region 2ybf A 1-2 disorder
       Region 2ybf A 3-152 order
 
Prediction
NeProc
Disorder 1-4
Order 5-152
AlphaFold
Disorder 1-1,152-152
Order 2-151
Pfam Hmmer
PF00179 8-145 1.4e-79
Function
Function in SwissProt
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.