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IID00559
 UniprotP83876
ProteinThioredoxin-like protein 4A
GeneTXNL4A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
142
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-142 Monomer :
 Evidence NMR 1pqn A Reference
       Region 1pqn A 2-128 order
       Region 1pqn A 2-2 high_rmsd
       Region 1pqn A 69-74 high_rmsd
       Region 1pqn A 97-99 high_rmsd
       Region 1pqn A 126-128 high_rmsd
 Evidence X-RAY 1qgv A Reference
       Region 1qgv A 1-1 disorder
       Region 1qgv A 2-95 order
       Region 1qgv A 96-101 disorder
       Region 1qgv A 102-137 order
       Region 1qgv A 138-142 disorder
Seq 1-142 Hetero dimer : IID00533Complex
 Evidence X-RAY 1syx E Reference
       Region 1syx E 1-2 disorder
       Region 1syx E 3-137 order
       Region 1syx E 138-142 disorder
 Evidence X-RAY 1syx C Reference
       Region 1syx C 1-2 disorder
       Region 1syx C 3-137 order
       Region 1syx C 138-142 disorder
 Evidence X-RAY 1syx A Reference
       Region 1syx A 1-2 disorder
       Region 1syx A 3-137 order
       Region 1syx A 138-142 disorder
Seq 4-137 Monomer : IID00187Complex
 Evidence X-RAY 4cdo C Reference
       Region 4cdo C 4-136 order
       Region 4cdo C 137-137 disorder
Seq 4-137 Hetero trimer : IID00187Complex,IID00533Complex
 Evidence X-RAY 4bws D Reference
       Region 4bws D 4-4 disorder
       Region 4bws D 5-137 order
 Evidence X-RAY 4bws A Reference
       Region 4bws A 4-4 disorder
       Region 4bws A 5-137 order
Seq 4-137 Hetero dimer : IID00187Complex
 Evidence X-RAY 4bwq A Reference
       Region 4bwq A 4-137 order
 Evidence X-RAY 4bwq C Reference
       Region 4bwq C 4-4 disorder
       Region 4bwq C 5-137 order
 Evidence X-RAY 4bwq G Reference
       Region 4bwq G 4-137 order
 Evidence X-RAY 4bwq E Reference
       Region 4bwq E 4-137 order
Seq 4-137 Monomer : IID00187Complex
 Evidence X-RAY 4cdo A Reference
       Region 4cdo A 4-137 order
Seqphosphorylation
    132-132 Phosphoserine
 
Prediction
NeProc
Order 1-142
AlphaFold
Disorder 1-3,138-142
Order 4-137
Pfam Hmmer
PF02966 4-136 1.9e-104
Function
Function in SwissProt
Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Biological Process
See also
Diagram with PDB data
PQBP1/TXNL4ACrystal structure of U5-15kD in a complex with PQBP1