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IID00560
 UniprotQ01974
ProteinTyrosine-protein kinase transmembrane receptor ROR2
GeneROR2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
943
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 452-753 Monomer :
 Evidence X-RAY 4gt4 B Reference
       Region 4gt4 B 452-463 disorder
       Region 4gt4 B 464-493 order
       Region 4gt4 B 494-500 disorder
       Region 4gt4 B 501-514 order
       Region 4gt4 B 515-515 disorder
       Region 4gt4 B 516-572 order
       Region 4gt4 B 573-580 disorder
       Region 4gt4 B 581-752 order
       Region 4gt4 B 753-753 disorder
 Evidence X-RAY 4gt4 A Reference
       Region 4gt4 A 452-463 disorder
       Region 4gt4 A 464-493 order
       Region 4gt4 A 494-500 disorder
       Region 4gt4 A 501-511 order
       Region 4gt4 A 512-512 disorder
       Region 4gt4 A 513-515 order
       Region 4gt4 A 516-516 disorder
       Region 4gt4 A 517-575 order
       Region 4gt4 A 576-580 disorder
       Region 4gt4 A 581-751 order
       Region 4gt4 A 752-753 disorder
Seq 464-751 Homo dimer :
 Evidence X-RAY 3zzw B Reference
       Region 3zzw B 464-465 disorder
       Region 3zzw B 466-570 order
       Region 3zzw B 571-590 disorder
       Region 3zzw B 591-750 order
       Region 3zzw B 751-751 disorder
 Evidence X-RAY 3zzw A Reference
       Region 3zzw A 464-465 disorder
       Region 3zzw A 466-569 order
       Region 3zzw A 570-585 disorder
       Region 3zzw A 586-750 order
       Region 3zzw A 751-751 disorder
Seqphosphorylation
    646-646 Phosphotyrosine; by autocatalysis
 
Prediction
NeProc
Disorder 1-54,394-400,426-459,576-584,754-943
Order 56-393,401-425,460-575,585-753
ProS 1-54,394-400,426-431,439-459,784-788,819-826,833-838,871-876,919-929,936-943
AlphaFold
Disorder 1-59,155-171,196-197,208-208,211-219,274-281,308-314,360-360,396-405,426-464,497-497,557-557,571-586,634-635,649-650,752-943
Order 60-154,172-195,198-207,209-210,220-273,282-307,315-359,361-395,406-425,465-496,498-556,558-570,587-633,636-648,651-751
Pfam Hmmer
PF07679 62-152 3.2e-21
PF01392 168-301 3.9e-45
PF00051 316-394 4.3e-34
PF07714 473-746 4.3e-136
SEG 12-26 ,765-783 ,789-803 ,839-872 ,905-924
Function
Function in SwissProt
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443).