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IID00561
 UniprotQ02410
ProteinAmyloid-beta A4 precursor protein-binding family A member 1
GeneAPBA1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
837
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 453-623 Hetero tetramer :
 Evidence X-RAY 1aqc B Reference
       Region 1aqc B 453-458 disorder
       Region 1aqc B 459-472 order
       Region 1aqc B 473-479 disorder
       Region 1aqc B 480-500 order
       Region 1aqc B 501-514 disorder
       Region 1aqc B 515-562 order
       Region 1aqc B 563-584 disorder
       Region 1aqc B 585-623 order
 Evidence X-RAY 1aqc A Reference
       Region 1aqc A 453-499 order
       Region 1aqc A 500-513 disorder
       Region 1aqc A 514-562 order
       Region 1aqc A 563-584 disorder
       Region 1aqc A 585-617 order
       Region 1aqc A 618-623 disorder
Seq 453-623 Hetero tetramer : IID00294Complex
 Evidence X-RAY 1x11 B Reference
       Region 1x11 B 453-458 disorder
       Region 1x11 B 459-472 order
       Region 1x11 B 473-480 disorder
       Region 1x11 B 481-502 order
       Region 1x11 B 503-513 disorder
       Region 1x11 B 514-560 order
       Region 1x11 B 561-584 disorder
       Region 1x11 B 585-623 order
 Evidence X-RAY 1x11 A Reference
       Region 1x11 A 453-497 order
       Region 1x11 A 498-513 disorder
       Region 1x11 A 514-560 order
       Region 1x11 A 561-579 disorder
       Region 1x11 A 580-621 order
       Region 1x11 A 622-623 disorder
Seq 655-741 Hetero dimer :
 Evidence NMR 1u38 A Reference
       Region 1u38 A 655-741 order
Seq 655-741 Monomer :
 Evidence NMR 1x45 A Reference
       Region 1x45 A 656-740 order
 Evidence NMR 1u37 A Reference
       Region 1u37 A 655-741 order
Seq 655-837 Monomer :
 Evidence NMR 1u3b A Reference
       Region 1u3b A 655-837 order
Seq 743-823 Monomer :
 Evidence NMR 1y7n A Reference
       Region 1y7n A 745-823 order
 Evidence NMR 1u39 A Reference
       Region 1u39 A 743-822 order
Seqphosphorylation
    367-367 Phosphoserine
    78-78 Phosphoserine
    242-242 Phosphoserine
    246-246 Phosphoserine
    248-248 Phosphoserine
    263-263 Phosphoserine
    280-280 Phosphoserine
    285-285 Phosphoserine
    305-305 Phosphothreonine
    313-313 Phosphoserine
    370-370 Phosphothreonine
    401-401 Phosphoserine
    403-403 Phosphoserine
    408-408 Phosphoserine
    568-568 Phosphoserine
 
Prediction
NeProc
Disorder 1-439,475-513,537-539,547-550,561-639
Order 440-474,514-536,540-546,551-560,640-837
ProS 1-23,83-137,154-171,178-192,197-204,210-218,235-245,267-277,308-314,376-381,388-403,485-508,537-539,547-550,587-625
AlphaFold
Disorder 1-339,342-342,360-448,474-476,502-513,561-585,620-620,622-652,676-679
Order 340-341,343-359,449-473,477-501,514-560,586-619,621-621,653-675,680-837
Pfam Hmmer
PF00640 461-618 1.3e-70
PF00595 656-740 5e-24
PF00595 747-820 1e-19
SEG 30-46 ,125-145 ,399-418
Function
Function in SwissProt
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).