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IID00564
 UniprotQ13542
ProteinEukaryotic translation initiation factor 4E-binding protein 2
GeneEIF4EBP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
120
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 18-62 Monomer :
 Evidence NMR 2mx4 A Reference
       Region 2mx4 A 18-62 order
       Region 2mx4 A 59-62 high_rmsd
Seq 47-65 Hetero dimer : IID00341Complex
 Evidence X-RAY 3am7 B Reference
       Region 3am7 B 47-65 order
Seqphosphorylation
    83-83 Phosphoserine
    70-70 Phosphothreonine; by MTOR
    65-65 Phosphoserine; by MTOR
    46-46 Phosphothreonine; by MTOR
    37-37 Phosphothreonine; by MTOR
 
Prediction
NeProc
Disorder 1-18,83-120
Order 19-82
ProS 12-18,83-86,112-120
AlphaFold
Disorder 1-9,85-114
Order 10-84,115-120
Pfam Hmmer
PF05456 1-120 4.5e-88
SEG 96-103
Function
Function in SwissProt
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).